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Use1 Gene Detail
Summary
  • Symbol
    Use1
  • Name
    unconventional SNARE in the ER 1 homolog (S. cerevisiae)
  • Synonyms
    2010315L10Rik, 5730403H22Rik, D12, mED2, Q-SNARE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914273
    NCBI Gene: 67023
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71819492-71822376 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914273
 protein coding gene Chr8:71819329-71822376 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033739
 protein coding gene Chr8:71756299-71759174 (+)
A/J MGP_AJ_G0033722
 protein coding gene Chr8:68838235-68841119 (+)
AKR/J MGP_AKRJ_G0033647
 protein coding gene Chr8:70854873-70857748 (+)
BALB/cJ MGP_BALBcJ_G0033718
 protein coding gene Chr8:69003757-69006632 (+)
C3H/HeJ MGP_C3HHeJ_G0033428
 protein coding gene Chr8:71441690-71444565 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034236
 protein coding gene Chr8:74499329-74502241 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031178
 protein coding gene Chr8:63474221-63477141 (+)
CAST/EiJ MGP_CASTEiJ_G0032753
 protein coding gene Chr8:70892867-70895750 (+)
CBA/J MGP_CBAJ_G0033406
 protein coding gene Chr8:77114397-77117272 (+)
DBA/2J MGP_DBA2J_G0033560
 protein coding gene Chr8:68565772-68568647 (+)
FVB/NJ MGP_FVBNJ_G0033502
 protein coding gene Chr8:67642533-67645408 (+)
LP/J MGP_LPJ_G0033647
 protein coding gene Chr8:71734088-71736963 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033549
 protein coding gene Chr8:79695496-79698380 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034253
 protein coding gene Chr8:70927068-70929943 (+)
PWK/PhJ MGP_PWKPhJ_G0032460
 protein coding gene Chr8:67838280-67841164 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032297
 protein coding gene Chr8:69889055-69891951 (+)
WSB/EiJ MGP_WSBEiJ_G0032868
 protein coding gene Chr8:71276084-71278959 (+)



Homology
more
  • Human Ortholog
    USE1, unconventional SNARE in the ER 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USE1, unconventional SNARE in the ER 1
  • Synonyms
    D12, MDS032, P31, SLT1
  • Links
    NCBI Gene ID: 55850
    neXtProt AC: NX_Q9NZ43
    UniProt: Q9NZ43

  • Chr Location
    19p13.11; chr19:17215346-17219829 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in complete embryonic lethality prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    25
  • cDNA Data
    115
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002395 Ensembl Gene Model | MGI Sequence Detail 2885 C57BL/6J ±  kb
    transcript ENSMUST00000110053 Ensembl | MGI Sequence Detail 1064 Not Applicable  
    polypeptide ENSMUSP00000105680 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 116
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924098, MGI:2142729
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:221535 Nieradka A, et al., Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment. PLoS One. 2014;9(9):e104631
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory