Wwp2 MGI Mouse Gene Detail - MGI:1914144 - WW domain containing E3 ubiquitin protein ligase 2

Symbol

Wwp2
Name

WW domain containing E3 ubiquitin protein ligase 2
Synonyms

1300010O06Rik, AIP2

Feature Type

protein coding gene
IDs

MGI:1914144
NCBI Gene: 66894
Alliance

genome feature page
Transcription Start Sites

10 TSS
Regulated by

Rr669429 (1 regulatory region)

Sequence Map

Chr8:108162997-108285227 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 54.15 cM
Mapping Data

2 experiments

SNPs within 2kb

2727 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914144	protein coding gene	Chr8:108162966-108285922 (+)
129S1/SvImJ	ENSMUSG00200013813	protein coding gene	Chr8:102557325-102565508 (+)
129S1/SvImJ	ENSMUSGG00200054600	protein coding gene	Chr8:102461251-102466245 (+)
A/J	ENSMUSG00195017048	protein coding gene	Chr8:102879775-102887958 (+)
A/J	ENSMUSGG00195055066	protein coding gene	Chr8:102783686-102788681 (+)
AKR/J	ENSMUSGG00220054378	protein coding gene	Chr8:102922683-102927677 (+)
AKR/J	ENSMUSG00220014422	protein coding gene	Chr8:103018762-103026946 (+)
BALB/cJ	ENSMUSG00180019185	protein coding gene	Chr8:102885456-102893641 (+)
BALB/cJ	ENSMUSGG00180055098	protein coding gene	Chr8:102789392-102794387 (+)
C3H/HeJ	ENSMUSG00175024299	protein coding gene	Chr8:102942482-102950666 (+)
C3H/HeJ	ENSMUSGG00175054726	protein coding gene	Chr8:102846412-102851407 (+)
C57BL/6NJ	ENSMUSG00215022223	protein coding gene	Chr8:102555353-102563538 (+)
C57BL/6NJ	ENSMUSGG00215055297	protein coding gene	Chr8:102459284-102464279 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031537	protein coding gene	Chr8:98571543-98689571 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210031466	protein coding gene	Chr8:102869823-102878008 (+)
CBA/J	ENSMUSGG00210054692	protein coding gene	Chr8:102773749-102778744 (+)
DBA/2J	ENSMUSG00185004886	protein coding gene	Chr8:108978595-108986778 (+)
DBA/2J	ENSMUSGG00185057579	protein coding gene	Chr8:108882526-108887520 (+)
FVB/NJ	ENSMUSGG00205054043	protein coding gene	Chr8:101757372-101762367 (+)
FVB/NJ	ENSMUSG00205015634	protein coding gene	Chr8:101853447-101861630 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055474	protein coding gene	Chr8:112562749-112567743 (+)
LP/J	ENSMUSG00230035298	protein coding gene	Chr8:112658821-112667001 (+)
NOD/ShiLtJ	ENSMUSG00190022410	protein coding gene	Chr8:103004033-103012217 (+)
NOD/ShiLtJ	ENSMUSGG00190054702	protein coding gene	Chr8:102907974-102912968 (+)
NZO/HlLtJ	ENSMUSG00225020234	protein coding gene	Chr8:116009425-116017608 (+)
NZO/HlLtJ	ENSMUSGG00225055616	protein coding gene	Chr8:115913365-115918359 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010032712	protein coding gene	Chr8:104750091-104873912 (+)
WSB/EiJ	no annotation

Human Ortholog

WWP2, WW domain containing E3 ubiquitin protein ligase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WWP2, WW domain containing E3 ubiquitin protein ligase 2
Synonyms

AIP2, WWp2-like
Links

HGNC:16804

NCBI Gene ID: 11060

UniProt: O00308
Chr Location

16q22.1; chr16:69762281-69944553 (+) GRCh38

MGI Vertebrate Homology

Wwp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WWP2
Protein SuperFamily

E3_ub_ligase_SMURF1
Gene Tree

Wwp2

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Phenotype Summary

13 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

380
Endonuclease-mediated

7
Gene trapped

369
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

374 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit decreased body size, domed skull, short snout, twisted snout and overgrown mandibular incisors. Mice homozygous for a different knock-out allele exhibit increased sensitivity to pIpC-treatment.

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All GO Annotations

65
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

948
Tissues

50
cDNA Data

182
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WWP2

Xenbase wwp2

ZFIN wwp2

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All Sequences

96
RefSeq

7
UniProt

8
CCDS

CCDS40467.1

Ensembl

ENSMUSG00000031930 (Evidence)
NCBI Gene

66894

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031930	Ensembl Gene Model \| MGI Sequence Detail	122231	C57BL/6J	± kb
transcript	ENSMUST00000166615	Ensembl \| MGI Sequence Detail	4314	Not Applicable
polypeptide	ENSMUSP00000132224	Ensembl \| MGI Sequence Detail	870	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000017465 NEDD4-like E3 ubiquitin-protein ligase WWP2

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR050409 E3 ubiquitin-protein ligase

IPR024928 E3 ubiquitin-protein ligase, SMURF1 type

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR001202 WW domain

IPR036020 WW domain superfamily
GlyGen

Q9DBH0 3 sites, 1 O-linked glycan (1 site)

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All nucleic 182

cDNA 182

Microarray probesets 6

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MGI:2142444, MGI:2142806

Summaries

All 80

Developmental Gene Expression 10

Gene Ontology 15

Phenotypes 22
Earliest

J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
Latest

J:371315 Gong J, et al., Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility. Nat Commun. 2025 Feb 10;16(1):1494

Wwp2 expression regulated by:

Feature	Feature Type	Location	Reference
Rr669429, regulatory region 669429	enhancer	Chr8:108195247-108196005	J:371315

TSS for Wwp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79310	Chr8:108162987-108163053 (+)	23 bp
Tssr79312	Chr8:108184409-108184422 (+)	21,419 bp
Tssr79313	Chr8:108184428-108184437 (+)	21,436 bp
Tssr79314	Chr8:108229194-108229229 (+)	66,215 bp
Tssr79315	Chr8:108229814-108229834 (+)	66,827 bp
Tssr79316	Chr8:108232889-108232896 (+)	69,896 bp
Tssr79317	Chr8:108271643-108271658 (+)	108,654 bp
Tssr79318	Chr8:108271664-108271678 (+)	108,674 bp
Tssr79319	Chr8:108271691-108271707 (+)	108,702 bp
Tssr79320	Chr8:108271715-108271739 (+)	108,730 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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