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Wfdc21 Gene Detail
Summary
  • Symbol
    Wfdc21
  • Name
    WAP four-disulfide core domain 21
  • Synonyms
    1100001G20Rik, Wdnm1-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913357
    NCBI Gene: 66107
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83637766-83643468 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913357
 protein coding gene Chr11:83637766-83643472 (+)
129S1/SvImJ ENSMUSG00200049056
 protein coding gene Chr11:80777713-80783413 (+)
A/J ENSMUSG00195044324
 protein coding gene Chr11:80632171-80637877 (+)
AKR/J ENSMUSG00220048359
 protein coding gene Chr11:80846102-80851747 (+)
BALB/cJ ENSMUSG00180041962
 protein coding gene Chr11:80827521-80833225 (+)
C3H/HeJ ENSMUSG00175034255
 protein coding gene Chr11:80779189-80784893 (+)
C57BL/6NJ ENSMUSG00215033152
 protein coding gene Chr11:80411179-80416881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016885
 protein coding gene Chr11:78982343-78988957 (+)
CAST/EiJ ENSTCUG00005043149
 protein coding gene Chr11:80348623-80354332 (+)
CBA/J ENSMUSG00210034938
 protein coding gene Chr11:80596821-80602525 (+)
DBA/2J ENSMUSG00185031111
 protein coding gene Chr11:80930761-80936408 (+)
FVB/NJ ENSMUSG00205028350
 protein coding gene Chr11:80715116-80720818 (+)
JF1/MsJ ENSUMUG00000013445
 protein coding gene Chr11:81241331-81247004 (+)
LP/J ENSMUSG00230024780
 protein coding gene Chr11:81946923-81952627 (+)
NOD/ShiLtJ ENSMUSG00190038367
 protein coding gene Chr11:80927431-80933133 (+)
NZO/HlLtJ ENSMUSG00225038547
 protein coding gene Chr11:84059444-84065141 (+)
PWK/PhJ ENSLUMG00010024650
 protein coding gene Chr11:80750115-80755787 (+)
SPRET/EiJ ENSMSPG00010038628
 protein coding gene Chr11:81214678-81217085 (+)
WSB/EiJ ENSIUOG00005030619
 protein coding gene Chr11:80734314-80740013 (+)



Homology
more
  • Human Ortholog
    WFDC21P, WAP four-disulfide core domain 21, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC21P, WAP four-disulfide core domain 21, pseudogene
  • Synonyms
    linc-DC, lnc-DC, LNCDC
  • Links
    NCBI Gene ID: 645638

  • Chr Location
    17q23.1; chr17:60083560-60091985 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    66
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051748 Ensembl Gene Model | MGI Sequence Detail 5703 C57BL/6J ±  kb
transcript ENSMUST00000070832 Ensembl | MGI Sequence Detail 434 Not Applicable  
polypeptide ENSMUSP00000064479 Ensembl | MGI Sequence Detail 63 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory