Rogdi MGI Mouse Gene Detail - MGI:1913299

Symbol

Rogdi
Name

rogdi homolog
Synonyms

0610011C19Rik, Lzf

Feature Type

protein coding gene
IDs

MGI:1913299
NCBI Gene: 66049
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:4826594-4831417 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.49 cM
Mapping Data

3 experiments

SNPs within 2kb

266 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913299	protein coding gene	Chr16:4826593-4831438 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022481	protein coding gene	Chr16:1534877-1539690 (-)
A/J	MGP_AJ_G0022443	protein coding gene	Chr16:1343129-1347961 (-)
AKR/J	MGP_AKRJ_G0022420	protein coding gene	Chr16:1540207-1545761 (-)
BALB/cJ	MGP_BALBcJ_G0022448	protein coding gene	Chr16:1495908-1501298 (-)
C3H/HeJ	MGP_C3HHeJ_G0022215	protein coding gene	Chr16:1560295-1565829 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022897	protein coding gene	Chr16:1620966-1626798 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020418	protein coding gene	Chr16:1275743-1281088 (-)
CAST/EiJ	MGP_CASTEiJ_G0021741	protein coding gene	Chr16:1564965-1569809 (-)
CBA/J	MGP_CBAJ_G0022184	protein coding gene	Chr16:1717720-1722758 (-)
DBA/2J	MGP_DBA2J_G0022315	protein coding gene	Chr16:1444171-1449040 (-)
FVB/NJ	MGP_FVBNJ_G0022290	protein coding gene	Chr16:1439124-1443936 (-)
LP/J	MGP_LPJ_G0022383	protein coding gene	Chr16:1521175-1527266 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022312	protein coding gene	Chr16:1553945-1558788 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022909	protein coding gene	Chr16:1511027-1517141 (-)
PWK/PhJ	MGP_PWKPhJ_G0021481	protein coding gene	Chr16:1521069-1525834 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021312	protein coding gene	Chr16:1598721-1603523 (-)
WSB/EiJ	MGP_WSBEiJ_G0021790	protein coding gene	Chr16:1528296-1533489 (-)

Human Ortholog

ROGDI, rogdi atypical leucine zipper

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ROGDI, rogdi atypical leucine zipper
Synonyms

KTZS, RAV2, ROGD1
Links

HGNC:29478

NCBI Gene ID: 79641

UniProt: Q9GZN7
Chr Location

16p13.3; chr16:4796968-4802880 (-) GRCh38

MGI Vertebrate Homology

Rogdi stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ROGDI
Gene Tree

Rogdi

Diseases

1 with Rogdi mouse models; 1 with human ROGDI associations

Human Disease

Mouse Models

Kohlschutter-Tonz syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

32 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice lacking exons 6-11 exhibit hyperactivity, memory deficits, increased susceptibility to induced seizures, less mature enamel that is hypomineralized, and recapitulate Kohlschutter-Tonz syndrome.

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All GO Annotations

24
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

81
cDNA Data

106
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rogdi

ZFIN rogdi

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All Sequences

52
RefSeq

5
UniProt

2
CCDS

CCDS79419.1

Ensembl

ENSMUSG00000022540 (Evidence)
NCBI Gene

66049

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022540	Ensembl Gene Model \| MGI Sequence Detail	4824	C57BL/6J	± kb
transcript	ENSMUST00000023191	Ensembl \| MGI Sequence Detail	1431	Not Applicable
polypeptide	ENSMUSP00000023191	Ensembl \| MGI Sequence Detail	309	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014156 protein rogdi

(term hierarchy)
InterPro Domains

IPR028241 RAVE subunit 2/Rogdi

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All nucleic 111

cDNA 107

Primer pair 4

Microarray probesets 3

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MGI:2146556, MGI:2146693

Summaries

All 33

Developmental Gene Expression 6

Diseases 1

Gene Ontology 5

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:344072 Jimenez-Armijo A, et al., The Rogdi knockout mouse is a model for Kohlschutter-Tonz syndrome. Sci Rep. 2024 Jan 3;14(1):445

TSS for Rogdi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139828	Chr16:4831424-4831433 (-)	-12 bp
Tssr139827	Chr16:4831369-4831422 (-)	21 bp
Tssr139826	Chr16:4830616-4830641 (-)	788 bp
Tssr139825	Chr16:4830599-4830609 (-)	813 bp
Tssr139824	Chr16:4829620-4829642 (-)	1,786 bp
Tssr139823	Chr16:4828507-4828536 (-)	2,895 bp
Tssr139822	Chr16:4828494-4828504 (-)	2,918 bp
Tssr139821	Chr16:4827934-4827989 (-)	3,455 bp
Tssr139820	Chr16:4827022-4827061 (-)	4,375 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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