Rogdi^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Rogdi^tm1.2Ics
• Name: rogdi homolog; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:7574508
• Gene: Rogdi Location: Chr16:4826594-4831417 bp, - strand Genetic Position: Chr16, 2.49 cM
• Alliance: Rogdi^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344072
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 11. The neomycin resistance cassette was removed via flp-mediated recombination. Exons 6-11 were deleted via cre-mediated recombination. (J:344072)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rogdi Mutation: 15 strains or lines available

Notes

S3 ES cells, an in-house ICS developed ES cell line of C57BL/6N origin, was used in J:344072.

References

• Original: J:344072 Jimenez-Armijo A, et al., The Rogdi knockout mouse is a model for Kohlschutter-Tonz syndrome. Sci Rep. 2024 Jan 3;14(1):445
• All: 1 reference(s)