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Ctsz Gene Detail
Summary
  • Symbol
    Ctsz
  • Name
    cathepsin Z
  • Synonyms
    cathepsin X, CTSX, D2Wsu143e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891190
    NCBI Gene: 64138
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:174269287-174280832 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 97.94 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891190
protein coding gene Chr2:174269286-174280832 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026967
protein coding gene Chr2:180782385-180793820 (-)
A/J MGP_AJ_G0026934
protein coding gene Chr2:173165755-173178046 (-)
AKR/J MGP_AKRJ_G0026905
protein coding gene Chr2:178382375-178393826 (-)
BALB/cJ MGP_BALBcJ_G0026943
protein coding gene Chr2:173558483-173572689 (-)
C3H/HeJ MGP_C3HHeJ_G0026685
protein coding gene Chr2:178761002-178772638 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027390
protein coding gene Chr2:185978067-185989737 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024759
protein coding gene Chr2:166401956-166413279 (-)
CAST/EiJ MGP_CASTEiJ_G0026144
protein coding gene Chr2:179488333-179501287 (-)
CBA/J MGP_CBAJ_G0026662
protein coding gene Chr2:192907756-192919222 (-)
DBA/2J MGP_DBA2J_G0026800
protein coding gene Chr2:172265294-172276735 (-)
FVB/NJ MGP_FVBNJ_G0026766
protein coding gene Chr2:170888896-170900912 (-)
LP/J MGP_LPJ_G0026901
protein coding gene Chr2:180695134-180707930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026785
protein coding gene Chr2:195798863-195813280 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027447
protein coding gene Chr2:178409488-178421163 (-)
PWK/PhJ MGP_PWKPhJ_G0025880
protein coding gene Chr2:172079081-172090519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025680
protein coding gene Chr2:177456546-177469151 (-)
WSB/EiJ MGP_WSBEiJ_G0026216
protein coding gene Chr2:179374049-179385590 (-)



Homology
more
  • Human Ortholog
    CTSZ, cathepsin Z
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSZ, cathepsin Z
  • Synonyms
    CTSX
  • Links
    NCBI Gene ID: 1522
    neXtProt AC: NX_Q9UBR2
    UniProt: Q9UBR2

  • Chr Location
    20q13.32; chr20:58985686-59008238 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
No abnormal pheotype detected in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64138 NCBI Gene Model | MGI Sequence Detail 11546 C57BL/6J ±  kb
transcript NM_022325 RefSeq | MGI Sequence Detail 1454 ZRU/MplStud  
polypeptide Q9WUU7 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 206
    Genomic 1
    cDNA 203
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory