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Robo2 Gene Detail
Summary
  • Symbol
    Robo2
  • Name
    roundabout guidance receptor 2
  • Synonyms
    2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890110
    NCBI Gene: 268902
  • Alliance
    gene page
  • Transcription Start Sites
    68 TSS
  • Regulated by
    Rr327654 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr16:73688727-75244270 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 42.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890110
 protein coding gene Chr16:73688725-75244331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022951
 protein coding gene Chr16:73822305-74361500 (-)
A/J MGP_AJ_G0022919
 protein coding gene Chr16:70604304-71114259 (-)
AKR/J MGP_AKRJ_G0022889
 protein coding gene Chr16:72760133-73270615 (-)
BALB/cJ MGP_BALBcJ_G0022921
 protein coding gene Chr16:70945735-71479356 (-)
C3H/HeJ MGP_C3HHeJ_G0022683
 protein coding gene Chr16:73173803-73710162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023369
 protein coding gene Chr16:76223877-76766793 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020872
 protein coding gene Chr16:69214626-69714131 (-)
CAST/EiJ MGP_CASTEiJ_G0022206
 protein coding gene Chr16:73556498-74097761 (-)
CBA/J MGP_CBAJ_G0022653
 protein coding gene Chr16:79419672-80012124 (-)
DBA/2J MGP_DBA2J_G0022786
 protein coding gene Chr16:70434539-70948695 (-)
FVB/NJ MGP_FVBNJ_G0022761
 protein coding gene Chr16:69821603-70337418 (-)
LP/J MGP_LPJ_G0022856
 protein coding gene Chr16:73614753-74155839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022779
 protein coding gene Chr16:82222200-82905595 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023386
 protein coding gene Chr16:73041447-73574891 (-)
PWK/PhJ MGP_PWKPhJ_G0021948
 protein coding gene Chr16:70679464-71187892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021778
 protein coding gene Chr16:72684688-73201224 (-)
WSB/EiJ MGP_WSBEiJ_G0022253
 protein coding gene Chr16:73212371-73757490 (-)



Homology
more
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
  • Synonyms
    SAX3
  • Links
    NCBI Gene ID: 6092
    UniProt: Q9HCK4

  • Chr Location
    3p12.3; chr3:75906675-77649964 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ROBO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 12 genetic backgrounds
    27 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1054
  • Tissues
    213
  • cDNA Data
    81
  • Literature Summary
    150
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052516 Ensembl Gene Model | MGI Sequence Detail 1555544 C57BL/6J ±  kb
    transcript ENSMUST00000249913 Ensembl | MGI Sequence Detail 8553 Not Applicable  
    polypeptide ENSMUSP00000160011 Ensembl | MGI Sequence Detail 1535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 92
      Primer pair 5
      Other 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919376, MGI:2146680, MGI:2442690, MGI:2444910
    References
    more
    • Summaries
      All 235
      Developmental Gene Expression 150
      Gene Ontology 14
      Phenotypes 94
    • Earliest
      J:62188 Murtra P, et al., Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature. 2000 May 11;405(6783):180-3
    • Latest
      J:366531 Dai W, et al., A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions. Cell Rep. 2025 Apr 22;44(4):115467
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory