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Angptl4 Gene Detail
Summary
  • Symbol
    Angptl4
  • Name
    angiopoietin-like 4
  • Synonyms
    BK89, FIAF, HFARP, NG27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888999
    NCBI Gene: 57875
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33993874-34000549 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888999
 protein coding gene Chr17:33992724-34000804 (-)
129S1/SvImJ ENSMUSG00200048165
 protein coding gene Chr17:29695588-29703670 (-)
A/J ENSMUSG00195034928
 protein coding gene Chr17:30567431-30575526 (-)
AKR/J ENSMUSG00220045547
 protein coding gene Chr17:29595057-29603152 (-)
BALB/cJ ENSMUSG00180032231
 protein coding gene Chr17:29953489-29961585 (-)
C3H/HeJ ENSMUSG00175052017
 protein coding gene Chr17:29476440-29484537 (-)
C57BL/6NJ ENSMUSG00215054025
 protein coding gene Chr17:29535749-29543831 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021416
 protein coding gene Chr17:30060917-30068769 (-)
CAST/EiJ ENSTCUG00005040083
 protein coding gene Chr17:30528591-30536689 (-)
CBA/J ENSMUSG00210045851
 protein coding gene Chr17:29303365-29311460 (-)
DBA/2J ENSMUSG00185043974
 protein coding gene Chr17:31972805-31980901 (-)
FVB/NJ ENSMUSG00205046943
 protein coding gene Chr17:29830514-29838612 (-)
JF1/MsJ ENSUMUG00000053039
 protein coding gene Chr17:31235585-31243638 (-)
LP/J ENSMUSG00230053053
 protein coding gene Chr17:33093972-33102052 (-)
NOD/ShiLtJ ENSMUSG00190051826
 protein coding gene Chr17:29452676-29460773 (-)
NZO/HlLtJ ENSMUSG00225051695
 protein coding gene Chr17:35121660-35129725 (-)
PWK/PhJ ENSLUMG00010052979
 protein coding gene Chr17:29071569-29079652 (-)
SPRET/EiJ ENSMSPG00010040498
 protein coding gene Chr17:30222634-30230693 (-)
WSB/EiJ ENSIUOG00005048983
 protein coding gene Chr17:30160783-30168827 (-)



Homology
more
  • Human Ortholog
    ANGPTL4, angiopoietin like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL4, angiopoietin like 4
  • Synonyms
    ARP4, FIAF, HARP, HFARP, NL2, PGAR, pp1158, TGQTL, UNQ171
  • Links
    NCBI Gene ID: 51129
    UniProt: Q9BY76

  • Chr Location
    19p13.2; chr19:8363223-8374371 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    4 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display decreased levels of triglycerides and cholesterol and a lower increase in body fat after exposure to gut microbiota.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    55
  • cDNA Data
    103
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57875 NCBI Gene Model | MGI Sequence Detail 6676 C57BL/6J ±  kb
    transcript NM_020581 RefSeq | MGI Sequence Detail 1916 C57BL/6  
    polypeptide Q9Z1P8 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 104
      Primer pair 5

      Microarray probesets 4
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:57564 Kim I, et al., Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999 Sep 10;274(37):26523-8
    • Latest
      J:380060 Yoo JA, et al., Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages. Am J Pathol. 2026 Mar;196(3):683-699
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory