Sequence Detail

ID/Version

Q9Z1P8 Q9JLX7 Q9JHX7 Q78ZJ9 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Angiopoietin-related protein 4;AltName: Full=425O18-1;AltName: Full=Angiopoietin-like protein 4;AltName: Full=Fasting-induced adipose factor {ECO:0000303|PubMed:10862772};AltName: Full=Hepatic fibrinogen/angiopoietin-related protein {ECO:000

Provider

SWISS-PROT

Sequence

Polypeptide 410 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Angptl4	angiopoietin-like 4	25	109	3	16

Sequence references in MGI

J:61082 Kim I, et al., Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J. 2000 Mar 15;346 Pt 3:603-10
J:62998 Yoon JC, et al., Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol. 2000 Jul;20(14):5343-9
J:64473 Kersten S, et al., Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem. 2000 Sep 15;275(37):28488-93
J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:89731 Abe K, et al., Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Mamm Genome. 2004 Apr;15(4):265-76
J:98462 Xu A, et al., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6086-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122968 Desai U, et al., Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71
J:129063 Cazes A, et al., Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res. 2006 Nov 24;99(11):1207-15
J:177790 Perdiguero EG, et al., Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice. J Biol Chem. 2011 Oct 21;286(42):36841-51
J:271463 Gusarova V, et al., Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nat Commun. 2018 Jun 13;9(1):2252