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Aldh1a3 Gene Detail
Summary
  • Symbol
    Aldh1a3
  • Name
    aldehyde dehydrogenase family 1, subfamily A3
  • Synonyms
    ALDH6, RALDH3, retinaldehyde dehydrogenase 3, V1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861722
    NCBI Gene: 56847
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr171333 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr7:66040640-66077225 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 35.73 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1308 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861722
 protein coding gene Chr7:66040638-66077265 (-)
129S1/SvImJ ENSMUSG00200011878
 protein coding gene Chr7:52749026-52792851 (-)
A/J ENSMUSG00195012546
 protein coding gene Chr7:57172195-57216024 (-)
AKR/J ENSMUSG00220019702
 protein coding gene Chr7:50674263-50718091 (-)
BALB/cJ ENSMUSG00180004305
 protein coding gene Chr7:53884557-53921050 (-)
C3H/HeJ ENSMUSG00175010432
 protein coding gene Chr7:54676016-54719841 (-)
C57BL/6NJ ENSMUSG00215014041
 protein coding gene Chr7:53816907-53853536 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029842
 protein coding gene Chr7:69133336-69168242 (-)
CAST/EiJ ENSTCUG00005012066
 protein coding gene Chr7:57357147-57393642 (-)
CBA/J ENSMUSG00210019847
 protein coding gene Chr7:54514526-54558353 (-)
DBA/2J ENSMUSG00185005664
 protein coding gene Chr7:58850518-58887058 (-)
FVB/NJ ENSMUSG00205004236
 protein coding gene Chr7:54516658-54560482 (-)
JF1/MsJ ENSUMUG00000007086
 protein coding gene Chr7:63596800-63633343 (-)
LP/J ENSMUSG00230018472
 protein coding gene Chr7:64938077-64974569 (-)
NOD/ShiLtJ ENSMUSG00190006996
 protein coding gene Chr7:54622791-54666612 (-)
NZO/HlLtJ ENSMUSG00225016476
 protein coding gene Chr7:63221561-63258067 (-)
PWK/PhJ ENSLUMG00010018418
 protein coding gene Chr7:53135574-53172188 (-)
SPRET/EiJ ENSMSPG00010003248
 protein coding gene Chr7:53517037-53552292 (-)
WSB/EiJ ENSIUOG00005004699
 protein coding gene Chr7:55059114-55095804 (-)



Homology
more
  • Human Ortholog
    ALDH1A3, aldehyde dehydrogenase 1 family member A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH1A3, aldehyde dehydrogenase 1 family member A3
  • Synonyms
    ALDH1A6, ALDH6, MCOP8, RALDH3
  • Links
    NCBI Gene ID: 220
    UniProt: P47895

  • Chr Location
    15q26.3; chr15:100861924-100916628 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALDH1A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show neonatal death and persistent hyperplastic primary vitreous. Homozygotes for a null allele have choanal atresia, ethmoturbinal hypoplasia, ventral lens rotation, short ventral retina and no Harderian gland. Homozygotes for another allele show thick neural retina and no vitreum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1450
  • Tissues
    386
  • cDNA Data
    66
  • Literature Summary
    119
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56847 NCBI Gene Model | MGI Sequence Detail 36586 C57BL/6J ±  kb
    transcript NM_053080 RefSeq | MGI Sequence Detail 3423 C57BL/6  
    polypeptide Q9JHW9 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      cDNA 69
      Primer pair 18
      Other 16
      Antibodies 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 119
      Gene Ontology 22
      Phenotypes 49
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory