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Gcm2 Gene Detail
Summary
  • Symbol
    Gcm2
  • Name
    glial cells missing homolog 2
  • Synonyms
    Gcm1-rs2
Location &
Maps
more
  • Sequence Map
    Chr13:41254903-41264511 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861438
 protein coding gene Chr13:41254903-41264511 (-)
129S1/SvImJ ENSMUSG00200011282
 protein coding gene Chr13:38528341-38537944 (-)
A/J ENSMUSG00195032863
 protein coding gene Chr13:37588202-37597809 (-)
AKR/J ENSMUSG00220027359
 protein coding gene Chr13:37375414-37385019 (-)
BALB/cJ ENSMUSG00180007468
 protein coding gene Chr13:37894675-37904280 (-)
C3H/HeJ ENSMUSG00175012475
 protein coding gene Chr13:37859550-37869155 (-)
C57BL/6NJ ENSMUSG00215007695
 protein coding gene Chr13:37995802-38005410 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018454
 protein coding gene Chr13:36393728-36402452 (-)
CAST/EiJ ENSTCUG00005031081
 protein coding gene Chr13:37896734-37906447 (-)
CBA/J ENSMUSG00210011257
 protein coding gene Chr13:37865239-37874842 (-)
DBA/2J ENSMUSG00185030921
 protein coding gene Chr13:38659560-38669163 (-)
FVB/NJ ENSMUSG00205024344
 protein coding gene Chr13:37614398-37624007 (-)
JF1/MsJ ENSUMUG00000022316
 protein coding gene Chr13:38192965-38202549 (-)
LP/J ENSMUSG00230013481
 protein coding gene Chr13:47997455-48007058 (-)
NOD/ShiLtJ ENSMUSG00190011938
 protein coding gene Chr13:38058714-38068324 (-)
NZO/HlLtJ ENSMUSG00225035465
 protein coding gene Chr13:41768800-41778409 (-)
PWK/PhJ ENSLUMG00010028399
 protein coding gene Chr13:37052682-37062287 (-)
SPRET/EiJ ENSMSPG00010010600
 protein coding gene Chr13:37086738-37095118 (-)
WSB/EiJ ENSIUOG00005027211
 protein coding gene Chr13:37191634-37201241 (-)



Homology
more
  • Human Ortholog
    GCM2, GCM transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCM2, GCM transcription factor 2
  • Synonyms
    FIH2, GCMB, hGCMb, HRPT4
  • Links
    NCBI Gene ID: 9247
    UniProt: O75603

  • Chr Location
    6p24.2; chr6:10873223-10882041 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gcm2 mouse models; 2 with human GCM2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    216
  • cDNA Data
    14
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107889 NCBI Gene Model | MGI Sequence Detail 9609 C57BL/6J ±  kb
    transcript NM_008104 RefSeq | MGI Sequence Detail 2879 C57BL/6  
    polypeptide O09102 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 16
      Primer pair 9
      Other 8
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37080, MGI:108044
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:391400 Miller D, et al., Reduced dosage of Kmt2d modifies Tbx1 haploinsufficiency toward phenotypes of 22q11.2DS. JCI Insight. 2026 Aug 24;11(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory