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Dnah10 Gene Detail
Summary
  • Symbol
    Dnah10
  • Name
    dynein, axonemal, heavy chain 10
  • Synonyms
    Dnahc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860299
    NCBI Gene: 56087
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124802149-124911372 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    508 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860299
 protein coding gene Chr5:124802149-124911372 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030104
 protein coding gene Chr5:128503976-128618266 (+)
A/J MGP_AJ_G0030069
 protein coding gene Chr5:123140915-123255996 (+)
AKR/J MGP_AKRJ_G0030005
 protein coding gene Chr5:127114441-127240084 (+)
BALB/cJ MGP_BALBcJ_G0030080
 protein coding gene Chr5:124479190-124589995 (+)
C3H/HeJ MGP_C3HHeJ_G0029797
 protein coding gene Chr5:127725024-127838755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030533
 protein coding gene Chr5:133493219-133619170 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027759
 protein coding gene Chr5:117677082-117789100 (+)
CAST/EiJ MGP_CASTEiJ_G0029206
 protein coding gene Chr5:126841283-126964277 (+)
CBA/J MGP_CBAJ_G0029767
 protein coding gene Chr5:138704326-138835946 (+)
DBA/2J MGP_DBA2J_G0029917
 protein coding gene Chr5:123160298-123273234 (+)
FVB/NJ MGP_FVBNJ_G0029873
 protein coding gene Chr5:122205691-122319850 (+)
LP/J MGP_LPJ_G0030006
 protein coding gene Chr5:129031612-129148052 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029904
 protein coding gene Chr5:142271672-142389843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030574
 protein coding gene Chr5:126734700-126853475 (+)
PWK/PhJ MGP_PWKPhJ_G0028920
 protein coding gene Chr5:121985499-122105592 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028757
 protein coding gene Chr5:124365936-124487699 (+)
WSB/EiJ MGP_WSBEiJ_G0029280
 protein coding gene Chr5:127421864-127544338 (+)



Homology
more
  • Human Ortholog
    DNAH10, dynein axonemal heavy chain 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH10, dynein axonemal heavy chain 10
  • Synonyms
    SPGF56
  • Links
    NCBI Gene ID: 196385
    neXtProt AC: NX_Q8IVF4
    UniProt: Q8IVF4

  • Chr Location
    12q24.31; chr12:123762188-123935720 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnah10 mouse models; 1 with human DNAH10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56087 NCBI Gene Model | MGI Sequence Detail 109224 C57BL/6J ±  kb
    transcript NM_019536 RefSeq | MGI Sequence Detail 14038 C57BL/6  
    polypeptide NP_062409 RefSeq | MGI Sequence Detail 4591 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:311550 Tu C, et al., Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2021 Aug 5;108(8):1466-1477
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory