Phenotypes Associated with This Genotype

Genotype
MGI:6780173

• Allelic Composition: Dnah10^em2Yxc/Dnah10^em2Yxc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:311550 )

• no significant difference in testes weight or size compared to heterozygous controls

• females are fertile and litter size is similar to controls

immotile sperm ( J:311550 )

♂

abnormal spermatogenesis ( J:311550 )

♂ • absence of elongated tails in stage VIIVIII seminiferous tubules

abnormal sperm flagellum morphology ( J:311550 )

♂ • sperm display multiple abnormalities including absent, coiled, short, and irregular flagella

♂ • display disorganized mitochondrial sheath, outer dense fibers, and microtubules

abnormal sperm mitochondrial sheath morphology ( J:311550 )

♂ • disorganized

absent sperm flagellum ( J:311550 )

♂

coiled sperm flagellum ( J:311550 )

♂

short sperm flagellum ( J:311550 )

♂

oligozoospermia ( J:311550 )

♂

male infertility ( J:311550 )

♂ • complete infertility in males

cellular

abnormal sperm flagellum morphology ( J:311550 )

♂ • sperm display multiple abnormalities including absent, coiled, short, and irregular flagella

♂ • display disorganized mitochondrial sheath, outer dense fibers, and microtubules

abnormal sperm mitochondrial sheath morphology ( J:311550 )

♂ • disorganized

absent sperm flagellum ( J:311550 )

♂

coiled sperm flagellum ( J:311550 )

♂

short sperm flagellum ( J:311550 )

♂

oligozoospermia ( J:311550 )

♂

immotile sperm ( J:311550 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spermatogenic failure		DOID:0111910	OMIM:PS258150	J:311550