About   Help   FAQ
Nell2 Gene Detail
Summary
  • Symbol
    Nell2
  • Name
    NEL-like 2
  • Synonyms
    A330108N19Rik, mel91
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858510
    NCBI Gene: 54003
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:95117321-95426677 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 49.39 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9407 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858510
 protein coding gene Chr15:94973111-95426677 (-)
129S1/SvImJ ENSMUSG00200048402
 protein coding gene Chr15:92175573-92629943 (-)
A/J ENSMUSG00195036330
 protein coding gene Chr15:92029377-92483809 (-)
AKR/J ENSMUSG00220047399
 protein coding gene Chr15:92037548-92487417 (-)
BALB/cJ ENSMUSG00180035157
 protein coding gene Chr15:91943496-92396842 (-)
C3H/HeJ ENSMUSG00175032362
 protein coding gene Chr15:92211708-92666329 (-)
C57BL/6NJ ENSMUSG00215050247
 protein coding gene Chr15:92006401-92459785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020199
 protein coding gene Chr15:88975183-89272801 (-)
CAST/EiJ ENSTCUG00005027488
 protein coding gene Chr15:91494192-91955395 (-)
CBA/J ENSMUSG00210030652
 protein coding gene Chr15:91992918-92447524 (-)
DBA/2J ENSMUSG00185033366
 protein coding gene Chr15:92041079-92495491 (-)
FVB/NJ ENSMUSG00205020742
 protein coding gene Chr15:91758905-92207950 (-)
JF1/MsJ ENSUMUG00000024427
 protein coding gene Chr15:91519699-91976472 (-)
LP/J ENSMUSG00230032850
 protein coding gene Chr15:95355253-95809637 (-)
NOD/ShiLtJ ENSMUSG00190040954
 protein coding gene Chr15:92047917-92508056 (-)
NZO/HlLtJ ENSMUSG00225041425
 protein coding gene Chr15:95658545-96112949 (-)
PWK/PhJ ENSLUMG00010033614
 protein coding gene Chr15:91693009-92147384 (-)
SPRET/EiJ ENSMSPG00010035598
 protein coding gene Chr15:93501004-93955322 (-)
WSB/EiJ ENSIUOG00005033008
 protein coding gene Chr15:92090586-92549826 (-)



Homology
more
  • Human Ortholog
    NELL2, neural EGFL like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NELL2, neural EGFL like 2
  • Synonyms
    NRP2
  • Links
    NCBI Gene ID: 4753
    UniProt: Q99435

  • Chr Location
    12q12; chr12:44508274-44921889 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display enhanced long term potentiation in the dentate gyrus of the hippocampus. Male mice homozygous for a null allele exhibit infertility, impaired binding of sperm to zona pellucida, and impaired sperm migration in female genital tract.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    977
  • Tissues
    83
  • cDNA Data
    63
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54003 NCBI Gene Model | MGI Sequence Detail 309357 C57BL/6J ±  kb
    transcript NM_001356950 RefSeq | MGI Sequence Detail 3429 C57BL/6  
    polypeptide Q61220 UniProt | EBI | MGI Sequence Detail 819 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011138 protein kinase C-binding protein NELL2
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR024731 NELL2-like, EGF domain
      IPR063324 NELL, C-terminal VWC-associated domain
      IPR049883 NOTCH1, EGF-like calcium-binding domain
      IPR051586 Protein kinase C-binding protein NELL
      IPR048287 Thrombospondin-like, N-terminal domain
      IPR001007 VWFC domain
    • GlyGen
      Q61220 9 sites, 11 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 63
      Primer pair 8
      Other 2
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146325, MGI:2444983
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory