Gene Expression Literature Summary

• Symbol: Nell2
• Name: NEL-like 2
• ID: MGI:1858510

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)		1													1
In situ RNA (section)	1		1		2	1	1	2	5	1	1	1	1	1	2
In situ RNA (whole mount)				1			1
RT-PCR					1		1	2	1
cDNA clones								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nell2  NEL-like 2   (Synonyms: A330108N19Rik, mel91)
Results	Reference
3*	J:309510 Beccari L, Jaquier G, Lopez-Delisle L, Rodriguez-Carballo E, Mascrez B, Gitto S, Woltering J, Duboule D, Dbx2 regulation in limbs suggests interTAD sharing of enhancers. Dev Dyn. 2021 Sep;250(9):1280-1299
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
5*	J:227045 Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M, Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science. 2015 Nov 20;350(6263):961-5
1	J:267504 Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA, Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56
1*	J:88577 Mu X, Beremand PD, Zhao S, Pershad R, Sun H, Scarpa A, Liang S, Thomas TL, Klein WH, Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development. 2004 Mar;131(6):1197-210
4*	J:272594 Nakamoto C, Durward E, Horie M, Nakamoto M, Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue. Development. 2019 Feb 18;146(4):dev170704
2*	J:185101 Nakamura R, Nakamoto C, Obama H, Durward E, Nakamoto M, Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions. J Biol Chem. 2012 Jan 27;287(5):3282-91
1*	J:286386 Pak JS, DeLoughery ZJ, Wang J, Acharya N, Park Y, Jaworski A, Ozkan E, NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun. 2020 Mar 20;11(1):1489
5*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
1	J:336866 Puelles L, Hidalgo-Sanchez M, The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
1*	J:276901 Taroc EZM, Lin JM, Tulloch AJ, Jaworski A, Forni PE, GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling. Front Cell Neurosci. 2019;13:70
1	J:174191 Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE, Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. PLoS Genet. 2011 Jul;7(7):e1002145
1	J:302089 Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T, The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget. 2016 Jun 21;7(25):37436-37455