Isg15 MGI Mouse Gene Detail - MGI:1855694 - ISG15 ubiquitin-like modifier

Symbol

Isg15
Name

ISG15 ubiquitin-like modifier
Synonyms

G1p2

Feature Type

protein coding gene
IDs

MGI:1855694
NCBI Gene: 100038882
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:156283912-156285253 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 88.61 cM
Mapping Data

3 experiments

SNPs within 2kb

22 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855694	protein coding gene	Chr4:156283881-156285275 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029248	protein coding gene	Chr4:160569247-160570639 (-)
A/J	MGP_AJ_G0029213	protein coding gene	Chr4:153804423-153805823 (-)
AKR/J	MGP_AKRJ_G0029161	protein coding gene	Chr4:157993922-157995314 (-)
BALB/cJ	MGP_BALBcJ_G0029229	protein coding gene	Chr4:154280470-154281871 (-)
C3H/HeJ	MGP_C3HHeJ_G0028950	protein coding gene	Chr4:158566040-158567328 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029678	protein coding gene	Chr4:166270275-166271670 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026922	protein coding gene	Chr4:146080380-146081810 (-)
CAST/EiJ	MGP_CASTEiJ_G0028362	protein coding gene	Chr4:155986457-155987857 (-)
CBA/J	MGP_CBAJ_G0028912	protein coding gene	Chr4:171314994-171316388 (-)
DBA/2J	MGP_DBA2J_G0029061	protein coding gene	Chr4:153823880-153825274 (-)
FVB/NJ	MGP_FVBNJ_G0029024	protein coding gene	Chr4:153071301-153074911 (-)
LP/J	MGP_LPJ_G0029151	protein coding gene	Chr4:160517933-160519325 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029051	protein coding gene	Chr4:174086982-174088935 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029710	protein coding gene	Chr4:158629996-158631390 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0027917	protein coding gene	Chr4:152877509-152878880 (-)
WSB/EiJ	MGP_WSBEiJ_G0028442	protein coding gene	Chr4:158806770-158808169 (-)

Human Ortholog

ISG15, ISG15 ubiquitin like modifier

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISG15, ISG15 ubiquitin like modifier
Synonyms

G1P2, hUCRP, IFI15, IMD38, IP17, UCRP
Links

HGNC:4053

NCBI Gene ID: 9636

neXtProt AC: NX_P05161

UniProt: P05161
Chr Location

1p36.33; chr1:1001138-1014540 (+) GRCh38

MGI Vertebrate Homology

Isg15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ISG15
Gene Tree

Isg15

Diseases

1 with human ISG15 associations

				Human Disease	Mouse Models
				immunodeficiency 38 IDs immunodeficiency 38 DOID:0111934 OMIM:616126 ORDO:319563

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile and do not display immunological abnormalities.

less

All GO Annotations

58
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

15
cDNA Data

4
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN isg15

less

All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS51405.1

Ensembl

ENSMUSG00000035692 (Evidence)
NCBI Gene

100038882

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035692	Ensembl Gene Model \| MGI Sequence Detail	1342	C57BL/6J	± kb
transcript	ENSMUST00000085425	Ensembl \| MGI Sequence Detail	703	Not Applicable
polypeptide	ENSMUSP00000082548	Ensembl \| MGI Sequence Detail	161	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000029563 ubiquitin-like protein ISG15

(term hierarchy)
PDB

5CHF, 5CHV, 5CHW, 5JZE, 5TL7, 5TLA, 6J62, 6YVA
InterPro Domains

IPR015496 Ubiquilin

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

less

All nucleic 8

cDNA 5

Primer pair 2

Other 1

Microarray probesets 2

less

MGI:3809535

Summaries

All 97

Developmental Gene Expression 14

Gene Ontology 17

Phenotypes 33
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346158 Chu L, et al., HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity. Cell Rep. 2024 Feb 28;43(3):113870

TSS for Isg15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45021	Chr4:156285294-156285303 (-)	-46 bp
Tssr45020	Chr4:156285281-156285290 (-)	-33 bp
Tssr45019	Chr4:156285248-156285262 (-)	-2 bp
Tssr45018	Chr4:156284491-156284494 (-)	760 bp
Tssr45017	Chr4:156284177-156284193 (-)	1,068 bp
Tssr45016	Chr4:156284111-156284123 (-)	1,136 bp
Tssr45015	Chr4:156284047-156284060 (-)	1,199 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23