Gene Expression Literature Summary

• Symbol: Isg15
• Name: ISG15 ubiquitin-like modifier
• ID: MGI:1855694

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E12.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18.5	P
Immunohistochemistry (section)		1								1
In situ RNA (section)					1
Northern blot		1		1				1
Western blot								1		1
RT-PCR	1	1	1	2	1	1	1		2	7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Isg15  ISG15 ubiquitin-like modifier   (Synonyms: G1p2)
Results	Reference
1	J:320348 Aditi, Downing SM, Schreiner PA, Kwak YD, Li Y, Shaw TI, Russell HR, McKinnon PJ, Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron. 2021 Dec 15;109(24):3962-3979.e6
3*	J:288419 Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM, Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. J Immunol. 2020 May 15;204(10):2791-2807
1	J:310901 de Reuver R, Dierick E, Wiernicki B, Staes K, Seys L, De Meester E, Muyldermans T, Botzki A, Lambrecht BN, Van Nieuwerburgh F, Vandenabeele P, Maelfait J, ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. Cell Rep. 2021 Aug 10;36(6):109500
2	J:330287 de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J, ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. Nature. 2022 Jul;607(7920):784-789
3	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
2*	J:181257 Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB, Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012 Jan 27;36(1):120-31
1	J:226998 Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ, Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
2*	J:316660 Henkes LE, Pru JK, Ashley RL, Anthony RV, Veeramachaneni DN, Gates KC, Hansen TR, Embryo mortality in Isg15-/- mice is exacerbated by environmental stress. Biol Reprod. 2015 Feb;92(2):36
1	J:141401 Okabe Y, Kawane K, Nagata S, IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol. 2008 Nov;38(11):3150-8
4	J:121928 Rempel LA, Austin KJ, Ritchie KJ, Yan M, Shen M, Zhang DE, Henkes LE, Hansen TR, Ubp43 gene expression is required for normal Isg15 expression and fetal development. Reprod Biol Endocrinol. 2007;5:13
1	J:333399 Rhee S, Paik DT, Yang JY, Nagelberg D, Williams I, Tian L, Roth R, Chandy M, Ban J, Belbachir N, Kim S, Zhang H, Phansalkar R, Wong KM, King DA, Valdez C, Winn VD, Morrison AJ, Wu JC, Red-Horse K, Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction. Eur Heart J. 2021 Nov 1;42(41):4264-4276
2*	J:333559 Rupani DN, Thege FI, Chandra V, Rajaei H, Cowan RW, Wormann SM, Le Roux O, Malaney P, Manning SL, Hashem J, Bailey-Lundberg J, Rhim AD, McAllister F, Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
1*	J:94874 Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S, Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol. 2005 Jan;6(1):49-56
1	J:261328 Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H, Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110