About   Help   FAQ
Dlc1 Gene Detail
Summary
  • Symbol
    Dlc1
  • Name
    deleted in liver cancer 1
  • Synonyms
    A730069N07Rik, Arhgap7, p122-RhoGAP, STARD12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354949
    NCBI Gene: 50768
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:37034905-37420297 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.05 cM, cytoband A4-B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11122 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354949
 protein coding gene Chr8:37034893-37420343 (-)
129S1/SvImJ ENSMUSG00200007216
 protein coding gene Chr8:32155380-32531887 (-)
A/J ENSMUSG00195005823
 protein coding gene Chr8:32636059-33012607 (-)
AKR/J ENSMUSG00220005543
 protein coding gene Chr8:32399993-32776526 (-)
BALB/cJ ENSMUSG00180002999
 protein coding gene Chr8:32179348-32555875 (-)
C3H/HeJ ENSMUSG00175014384
 protein coding gene Chr8:32341776-32718263 (-)
C57BL/6NJ ENSMUSG00215007752
 protein coding gene Chr8:32104275-32475442 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030986
 protein coding gene Chr8:30769149-31167679 (-)
CAST/EiJ ENSTCUG00005005484
 protein coding gene Chr8:32300248-32665172 (-)
CBA/J ENSMUSG00210012609
 protein coding gene Chr8:32164753-32541285 (-)
DBA/2J ENSMUSG00185002057
 protein coding gene Chr8:38091016-38467507 (-)
FVB/NJ ENSMUSG00205002205
 protein coding gene Chr8:31377404-31752645 (-)
JF1/MsJ ENSUMUG00000005401
 protein coding gene Chr8:39784732-40156012 (-)
LP/J ENSMUSG00230008626
 protein coding gene Chr8:41740968-42131989 (-)
NOD/ShiLtJ ENSMUSG00190015396
 protein coding gene Chr8:32213241-32589735 (-)
NZO/HlLtJ ENSMUSG00225014840
 protein coding gene Chr8:45343020-45734043 (-)
PWK/PhJ ENSLUMG00010012320
 protein coding gene Chr8:31994833-32366870 (-)
SPRET/EiJ ENSMSPG00010004439
 protein coding gene Chr8:32733231-33130943 (-)
WSB/EiJ ENSIUOG00005005473
 protein coding gene Chr8:32987941-33360288 (-)



Homology
more
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
  • Synonyms
    ARHGAP7, HP, p122-RhoGAP, STARD12
  • Links
    NCBI Gene ID: 10395
    UniProt: Q96QB1

  • Chr Location
    8p22; chr8:13083361-13604620 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DLC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    30
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031523 Ensembl Gene Model | MGI Sequence Detail 385393 C57BL/6J ±  kb
    transcript ENSMUST00000163663 Ensembl | MGI Sequence Detail 5113 Not Applicable  
    polypeptide ENSMUSP00000132812 Ensembl | MGI Sequence Detail 1543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 21
      Primer pair 7
      Other 2
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442088
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:60865 Yuan BZ, et al., Assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22-->p21. Cytogenet Cell Genet. 1999;87(3-4):189-90
    • Latest
      J:352711 Zhao R, et al., Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Elife. 2024 Jun 14;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory