About   Help   FAQ
E2f6 Gene Detail
Summary
  • Symbol
    E2f6
  • Name
    E2F transcription factor 6
  • Synonyms
    EMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354159
    NCBI Gene: 50496
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:16860932-16876753 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354159
protein coding gene Chr12:16860932-16889743 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019612
protein coding gene Chr12:14213656-14231015 (+)
A/J MGP_AJ_G0019579
protein coding gene Chr12:13715505-13732683 (+)
AKR/J MGP_AKRJ_G0019549
protein coding gene Chr12:14367409-14383200 (+)
BALB/cJ MGP_BALBcJ_G0019555
protein coding gene Chr12:13961002-13978216 (+)
C3H/HeJ MGP_C3HHeJ_G0019360
protein coding gene Chr12:14276404-14291776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020003
protein coding gene Chr12:14680208-14696003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017629
protein coding gene Chr12:13212388-13221913 (+)
CAST/EiJ MGP_CASTEiJ_G0018915
protein coding gene Chr12:14157741-14175838 (+)
CBA/J MGP_CBAJ_G0019331
protein coding gene Chr12:15492468-15509363 (+)
DBA/2J MGP_DBA2J_G0019444
protein coding gene Chr12:13632051-13647848 (+)
FVB/NJ MGP_FVBNJ_G0019435
protein coding gene Chr12:13518419-13534199 (+)
LP/J MGP_LPJ_G0019515
protein coding gene Chr12:14333552-14349300 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019470
protein coding gene Chr12:15378875-15395899 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020042
protein coding gene Chr12:14056057-14071900 (+)
PWK/PhJ MGP_PWKPhJ_G0018681
protein coding gene Chr12:13667257-13683246 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018471
protein coding gene Chr12:14263751-14279673 (+)
WSB/EiJ MGP_WSBEiJ_G0018966
protein coding gene Chr12:14170487-14186307 (+)



Homology
more
  • Human Ortholog
    E2F6, E2F transcription factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F6, E2F transcription factor 6
  • Synonyms
    E2F-6
  • Links
    NCBI Gene ID: 1876
    neXtProt AC: NX_O75461
    UniProt: O75461

  • Chr Location
    2p25.1; chr2:11444375-11466177 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both homozygous and heterozygous null mice exhibit subtle posterior transformations of the axial skeleton with incomplete penetrance. In addition to skeletal transformations, male mice homozygous for one knock-out allele display defective spermatocyte development and Leydig cell hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50496 NCBI Gene Model | MGI Sequence Detail 15822 C57BL/6J ±  kb
    transcript NR_027677 RefSeq | MGI Sequence Detail 2512 ZRU/MplStud  
    polypeptide O54917 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 67
      Primer pair 8
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144836
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:44763 Morkel M, et al., An E2F-like repressor of transcription [letter]. Nature. 1997 Dec 11;390(6660):567-8
    • Latest
      J:332407 Gu Y, et al., Multi-omics profiling visualizes dynamics of cardiac development and functions. Cell Rep. 2022 Dec 27;41(13):111891

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory