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Glrx3 Gene Detail
Summary
  • Symbol
    Glrx3
  • Name
    glutaredoxin 3
  • Synonyms
    PICOT, PKC interacting cousin of thioredoxin, Txnl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353653
    NCBI Gene: 30926
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:137039343-137070323 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 82.32 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353653
 protein coding gene Chr7:137039302-137071360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033140
 protein coding gene Chr7:142373736-142413162 (+)
A/J MGP_AJ_G0033122
 protein coding gene Chr7:138389425-138421145 (+)
AKR/J MGP_AKRJ_G0033054
 protein coding gene Chr7:142110092-142144464 (+)
BALB/cJ MGP_BALBcJ_G0033123
 protein coding gene Chr7:138134119-138164676 (+)
C3H/HeJ MGP_C3HHeJ_G0032837
 protein coding gene Chr7:141949383-141980968 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033634
 protein coding gene Chr7:147698003-147731299 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030607
 protein coding gene Chr7:139573293-139602650 (+)
CAST/EiJ MGP_CASTEiJ_G0032167
 protein coding gene Chr7:134140555-134174422 (+)
CBA/J MGP_CBAJ_G0032810
 protein coding gene Chr7:152672680-152706955 (+)
DBA/2J MGP_DBA2J_G0032962
 protein coding gene Chr7:136374443-136405538 (+)
FVB/NJ MGP_FVBNJ_G0032915
 protein coding gene Chr7:136232112-136264987 (+)
LP/J MGP_LPJ_G0033056
 protein coding gene Chr7:143911177-143942820 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033654
 protein coding gene Chr7:141123659-141156289 (+)
PWK/PhJ MGP_PWKPhJ_G0031873
 protein coding gene Chr7:129525429-129557246 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031718
 protein coding gene Chr7:127883087-127919987 (+)
WSB/EiJ MGP_WSBEiJ_G0032278
 protein coding gene Chr7:142014994-142048375 (+)



Homology
more
  • Human Ortholog
    GLRX3, glutaredoxin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRX3, glutaredoxin 3
  • Synonyms
    GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3
  • Links
    NCBI Gene ID: 10539
    neXtProt AC: NX_O76003
    UniProt: O76003

  • Chr Location
    10q26.3; chr10:130136391-130184521 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele die during late organogenesis/early fetal development with decreased embryo size, pericardial effusions and open anterior neural tubes. Homozygotes for a null allele show decreased embryo size, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    46
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031068 Ensembl Gene Model | MGI Sequence Detail 30981 C57BL/6J ±  kb
    transcript ENSMUST00000211496 Ensembl | MGI Sequence Detail 3440 Not Applicable  
    polypeptide ENSMUSP00000147803 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:60175 Witte S, et al., Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem. 2000 Jan 21;275(3):1902-9
    • Latest
      J:289611 Donelson J, et al., Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 Apr;7(8):e14071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory