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Nr4a1 Gene Detail
Summary
  • Symbol
    Nr4a1
  • Name
    nuclear receptor subfamily 4, group A, member 1
  • Synonyms
    Gfrp, GFRP1, Hbr1, Hbr-1, Hmr, N10, NGFI-B, NP10, Nur77, TIS1, TR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352454
    NCBI Gene: 15370
  • Alliance
  • Transcription Start Sites
    71 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101152150-101172676 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.64 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352454
protein coding gene Chr15:101151783-101172676 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022368
protein coding gene Chr15:103314940-103322804 (+)
A/J MGP_AJ_G0022330
protein coding gene Chr15:99230474-99238344 (+)
AKR/J MGP_AKRJ_G0022306
protein coding gene Chr15:102255429-102266633 (+)
BALB/cJ MGP_BALBcJ_G0022334
protein coding gene Chr15:99332354-99340218 (+)
C3H/HeJ MGP_C3HHeJ_G0022104
protein coding gene Chr15:102340228-102348151 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022782
protein coding gene Chr15:107157537-107165506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020307
protein coding gene Chr15:94965856-94973581 (+)
CAST/EiJ MGP_CASTEiJ_G0021629
protein coding gene Chr15:103191769-103199703 (+)
CBA/J MGP_CBAJ_G0022073
protein coding gene Chr15:110876572-110884436 (+)
DBA/2J MGP_DBA2J_G0022200
protein coding gene Chr15:98562172-98569994 (+)
FVB/NJ MGP_FVBNJ_G0022179
protein coding gene Chr15:97612575-97620838 (+)
LP/J MGP_LPJ_G0022271
protein coding gene Chr15:103457474-103465338 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022200
protein coding gene Chr15:114566048-114573875 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022796
protein coding gene Chr15:102280298-102288201 (+)
PWK/PhJ MGP_PWKPhJ_G0021368
protein coding gene Chr15:98718503-98726449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021200
protein coding gene Chr15:102177486-102185268 (+)
WSB/EiJ MGP_WSBEiJ_G0021679
protein coding gene Chr15:102901442-102909406 (+)



Homology
more
  • Human Ortholog
    NR4A1, nuclear receptor subfamily 4 group A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR4A1, nuclear receptor subfamily 4 group A member 1
  • Synonyms
    GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
  • Links
    NCBI Gene ID: 3164
    neXtProt AC: NX_P22736
    UniProt: P22736

  • Chr Location
    12q13.13; chr12:52022832-52059507 (+)  GRCh38

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 6 genetic backgrounds
    25 phenotypes from multigenic genotypes
    154 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion. Homozygous KO decreases apoptosis and increases proliferation of B cell stimulated by a single antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023034 Ensembl Gene Model | MGI Sequence Detail 20527 C57BL/6J ±  kb
    transcript ENSMUST00000023779 Ensembl | MGI Sequence Detail 2477 Not Applicable  
    polypeptide ENSMUSP00000023779 Ensembl | MGI Sequence Detail 601 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011408 nuclear receptor subfamily 4 immunity group A member 1
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003071 Nuclear receptor subfamily 4 group A member 1
      IPR003070 Nuclear receptor subfamily 4 group A member 1-3
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 66
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10057, MGD-MRK-10641, MGD-MRK-10642, MGI:95699, MGI:96029
    References
    more
    • Summaries
      All 286
      Developmental Gene Expression 26
      Diseases 2
      Gene Ontology 26
      Phenotypes 154
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:347110 Srirat T, et al., NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment. Cell Rep. 2024 Mar 26;43(3):113898

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory