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Magel2 Gene Detail
Summary
  • Symbol
    Magel2
  • Name
    MAGE family member L2
  • Synonyms
    Mage-l2, NDNL1, nM15, ns7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351648
    NCBI Gene: 27385
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:62026758-62031388 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.37 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351648
 protein coding gene Chr7:62026727-62031388 (+)
129S1/SvImJ ENSMUSG00200008448
 protein coding gene Chr7:48759785-48764415 (+)
A/J ENSMUSG00195012916
 protein coding gene Chr7:53180117-53184747 (+)
AKR/J ENSMUSG00220010757
 protein coding gene Chr7:46688628-46693258 (+)
BALB/cJ ENSMUSG00180010631
 protein coding gene Chr7:49897910-49902540 (+)
C3H/HeJ ENSMUSG00175010795
 protein coding gene Chr7:50642420-50647050 (+)
C57BL/6NJ ENSMUSG00215001941
 protein coding gene Chr7:49810111-49814741 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029818
 protein coding gene Chr7:65283032-65287684 (+)
CAST/EiJ ENSTCUG00005012009
 protein coding gene Chr7:53431798-53436428 (+)
CBA/J ENSMUSG00210017389
 protein coding gene Chr7:50544010-50548640 (+)
DBA/2J ENSMUSG00185005960
 protein coding gene Chr7:54930409-54935036 (+)
FVB/NJ ENSMUSG00205004093
 protein coding gene Chr7:50473457-50478087 (+)
JF1/MsJ ENSUMUG00000010536
 protein coding gene Chr7:59665303-59669930 (+)
LP/J ENSMUSG00230019873
 protein coding gene Chr7:60895203-60899833 (+)
NOD/ShiLtJ ENSMUSG00190003442
 protein coding gene Chr7:50652755-50657385 (+)
NZO/HlLtJ ENSMUSG00225009595
 protein coding gene Chr7:59190556-59195186 (+)
PWK/PhJ ENSLUMG00010002222
 protein coding gene Chr7:49208776-49213406 (+)
SPRET/EiJ ENSMSPG00010001416
 protein coding gene Chr7:49486602-49491199 (+)
WSB/EiJ ENSIUOG00005004566
 protein coding gene Chr7:51062162-51066792 (+)



Homology
more
  • Human Ortholog
    MAGEL2, MAGE family member L2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEL2, MAGE family member L2
  • Synonyms
    NDNL1, nM15, PWLS, SHFYNG
  • Links
    NCBI Gene ID: 54551
    UniProt: Q9UJ55

  • Chr Location
    15q11.2; chr15:23643549-23647867 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Magel2 mouse models; 1 with human MAGEL2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 3 alleles in 5 genetic backgrounds
    1 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele that is inherited paternally exhibit some postnatal lethality, reduced male fertility, abnormal circadian rhythm, and hypoactivity. Mice heterozygous for another paternal knock-out allele exhibit 50% neonatal lethalityassociated with weak suckling activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    138
  • cDNA Data
    38
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056972 Ensembl Gene Model | MGI Sequence Detail 4631 C57BL/6J ±  kb
    transcript ENSMUST00000080403 Ensembl | MGI Sequence Detail 4631 Not Applicable  
    polypeptide ENSMUSP00000079265 Ensembl | MGI Sequence Detail 1284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 38
      Primer pair 9
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 35
      Diseases 6
      Gene Ontology 11
      Phenotypes 71
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:390137 Otani Y, et al., Restoration of axon initial segment plasticity via chemogenetic activation rescues autism-related behaviors. Cell Death Dis. 2026 May 19;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory