About   Help   FAQ
Clnk Gene Detail
Summary
  • Symbol
    Clnk
  • Name
    cytokine-dependent hematopoietic cell linker
  • Synonyms
    MIST
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351468
    NCBI Gene: 27278
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38863805-39034155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 20.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351468
 protein coding gene Chr5:38858951-39034201 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029515
 protein coding gene Chr5:37141054-37318586 (-)
A/J MGP_AJ_G0029481
 protein coding gene Chr5:35883001-36053871 (-)
AKR/J MGP_AKRJ_G0029431
 protein coding gene Chr5:37230744-37403849 (-)
BALB/cJ MGP_BALBcJ_G0029492
 protein coding gene Chr5:36374576-36541092 (-)
C3H/HeJ MGP_C3HHeJ_G0029215
 protein coding gene Chr5:37220709-37399731 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029946
 protein coding gene Chr5:39096477-39268255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027184
 protein coding gene Chr5:33549975-33717835 (-)
CAST/EiJ MGP_CASTEiJ_G0028623
 protein coding gene Chr5:36403069-36582929 (-)
CBA/J MGP_CBAJ_G0029182
 protein coding gene Chr5:40009829-40188506 (-)
DBA/2J MGP_DBA2J_G0029329
 protein coding gene Chr5:36012369-36186315 (-)
FVB/NJ MGP_FVBNJ_G0029288
 protein coding gene Chr5:35510228-35672901 (-)
LP/J MGP_LPJ_G0029415
 protein coding gene Chr5:37593536-37777493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029318
 protein coding gene Chr5:40734516-40918814 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029979
 protein coding gene Chr5:36734105-36901904 (-)
PWK/PhJ MGP_PWKPhJ_G0028347
 protein coding gene Chr5:35185389-35356880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028181
 protein coding gene Chr5:36182325-36361616 (-)
WSB/EiJ MGP_WSBEiJ_G0028704
 protein coding gene Chr5:36810999-36991853 (-)



Homology
more
  • Human Ortholog
    CLNK, cytokine dependent hematopoietic cell linker
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLNK, cytokine dependent hematopoietic cell linker
  • Synonyms
    MIST
  • Links
    NCBI Gene ID: 116449
    neXtProt AC: NX_Q7Z7G1
    UniProt: Q7Z7G1

  • Chr Location
    4p16.1; chr4:10486395-10734846 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele display altered natural killer (NK) T cell physiology and enhanced NK cell cytolysis. Mice homozygous for knock-out allele display abnormal mast cell physiology as well as enhanced NK cell cytolysis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039315 Ensembl Gene Model | MGI Sequence Detail 170351 C57BL/6J ±  kb
    transcript ENSMUST00000169819 Ensembl | MGI Sequence Detail 1700 Not Applicable  
    polypeptide ENSMUSP00000128473 Ensembl | MGI Sequence Detail 435 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Diseases 1
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:277871 Xu M, et al., Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. Biochem Biophys Res Commun. 2015 Jul 31;463(3):275-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory