Clnk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clnk
cytokine-dependent hematopoietic cell linker
MGI:1351468

16 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clnk^{em1(IMPC)Ccpcz}/Clnk^{em1(IMPC)Ccpcz} C57BL/6NCrl-Clnk^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased skeletal muscle mass	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	single kidney	J:211773
Clnk^tm1Rygo/Clnk^tm1Rygo B6.129P2-Clnk^tm1Rygo	abnormal interferon-gamma secretion	J:131738
	abnormal NK T cell physiology	J:131738
	decreased interleukin-4 secretion	J:131738
	normal immune system phenotype	J:131738
	increased natural killer cell mediated cytotoxicity	J:131738
Clnk^tm1Rygo/Clnk^tm1Rygo involves: 129P2/OlaHsd * BALB/c	normal immune system phenotype	J:131621
	increased interferon-gamma secretion	J:131621
	increased natural killer cell mediated cytotoxicity	J:131621
Clnk^tm1Vei/Clnk^tm1Vei involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal mast cell physiology	J:91590
	normal immune system phenotype	J:91590
	increased natural killer cell mediated cytotoxicity	J:91590

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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