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Amfr Gene Detail
Summary
  • Symbol
    Amfr
  • Name
    autocrine motility factor receptor
  • Synonyms
    gp78
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345634
    NCBI Gene: 23802
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94698216-94739268 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 45.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345634
 protein coding gene Chr8:94698216-94739470 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033950
 protein coding gene Chr8:95358609-95401070 (-)
A/J MGP_AJ_G0033933
 protein coding gene Chr8:91651072-91690929 (-)
AKR/J MGP_AKRJ_G0033859
 protein coding gene Chr8:94171006-94210897 (-)
BALB/cJ MGP_BALBcJ_G0033925
 protein coding gene Chr8:91740506-91782099 (-)
C3H/HeJ MGP_C3HHeJ_G0033635
 protein coding gene Chr8:94869378-94910949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034446
 protein coding gene Chr8:98847043-98891772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031387
 protein coding gene Chr8:85452837-85494386 (-)
CAST/EiJ MGP_CASTEiJ_G0032967
 protein coding gene Chr8:94432410-94476808 (-)
CBA/J MGP_CBAJ_G0033611
 protein coding gene Chr8:102133738-102178065 (-)
DBA/2J MGP_DBA2J_G0033765
 protein coding gene Chr8:91117418-91158723 (-)
FVB/NJ MGP_FVBNJ_G0033712
 protein coding gene Chr8:90086157-90125909 (-)
LP/J MGP_LPJ_G0033857
 protein coding gene Chr8:95506231-95551267 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033754
 protein coding gene Chr8:104416282-104462339 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034464
 protein coding gene Chr8:94316756-94359346 (-)
PWK/PhJ MGP_PWKPhJ_G0032669
 protein coding gene Chr8:90476062-90517538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032506
 protein coding gene Chr8:93136314-93177833 (-)
WSB/EiJ MGP_WSBEiJ_G0033079
 protein coding gene Chr8:94748838-94873396 (-)



Homology
more
  • Human Ortholog
    AMFR, autocrine motility factor receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMFR, autocrine motility factor receptor
  • Synonyms
    GP78, RNF45
  • Links
    NCBI Gene ID: 267
    neXtProt AC: NX_Q9UKV5
    UniProt: Q9UKV5

  • Chr Location
    16q13; chr16:56361452-56425538 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice for a gene-trapped null allele are obese and develop liver steatosis and/or hepatic inflammation resembling nonalcoholic steatohepatitis. Some mice develop liver tumors. Mice homozygous for another knock-out allele exhibit normal HMGCR turnover in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    62
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23802 NCBI Gene Model | MGI Sequence Detail 41053 C57BL/6J ±  kb
    transcript NM_011787 RefSeq | MGI Sequence Detail 3711 C57BL/6  
    polypeptide Q9R049 UniProt | EBI | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 12
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:56927 Shimizu K, et al., The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 1999 Aug 6;456(2):295-300
    • Latest
      J:311437 Liu SS, et al., The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021 Sep 14;54(9):2042-2056.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    05/30/2023
    MGI 6.22     		The Jackson Laboratory