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Chd4 Gene Detail
Summary
  • Symbol
    Chd4
  • Name
    chromodomain helicase DNA binding protein 4
  • Synonyms
    9530019N15Rik, D6Ertd380e, MGC:11769, Mi-2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344380
    NCBI Gene: 107932
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125073144-125107554 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344380
 protein coding gene Chr6:125072943-125107554 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031285
 protein coding gene Chr6:128422183-128460379 (+)
A/J MGP_AJ_G0031255
 protein coding gene Chr6:123579594-123615038 (+)
AKR/J MGP_AKRJ_G0031183
 protein coding gene Chr6:126955731-126990935 (+)
BALB/cJ MGP_BALBcJ_G0031263
 protein coding gene Chr6:123175298-123211098 (+)
C3H/HeJ MGP_C3HHeJ_G0030986
 protein coding gene Chr6:127010644-127052480 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031719
 protein coding gene Chr6:131803053-131838375 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028869
 protein coding gene Chr6:120783469-120817619 (+)
CAST/EiJ MGP_CASTEiJ_G0030367
 protein coding gene Chr6:127222729-127259959 (+)
CBA/J MGP_CBAJ_G0030947
 protein coding gene Chr6:136856215-136899375 (+)
DBA/2J MGP_DBA2J_G0031103
 protein coding gene Chr6:122510642-122546164 (+)
FVB/NJ MGP_FVBNJ_G0031053
 protein coding gene Chr6:121420878-121455455 (+)
LP/J MGP_LPJ_G0031183
 protein coding gene Chr6:128587596-128626364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031091
 protein coding gene Chr6:140897023-140933415 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031754
 protein coding gene Chr6:126852139-126892781 (+)
PWK/PhJ MGP_PWKPhJ_G0030082
 protein coding gene Chr6:120750902-120788922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029911
 protein coding gene Chr6:124934644-124968331 (+)
WSB/EiJ MGP_WSBEiJ_G0030452
 protein coding gene Chr6:127220111-127257791 (+)



Homology
more
  • Human Ortholog
    CHD4, chromodomain helicase DNA binding protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHD4, chromodomain helicase DNA binding protein 4
  • Synonyms
    CHD-4, Mi-2b, Mi2-BETA, SIHIWES
  • Links
    NCBI Gene ID: 1108
    neXtProt AC: NX_Q14839
    UniProt: Q14839

  • Chr Location
    12p13.31; chr12:6570082-6614524 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chd4 mouse models; 6 with human CHD4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 6 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality between E3.5 and E4.5, absent blastocoele failure of trophectoderm function and increased apoptosis in blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    104
  • cDNA Data
    20
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107932 NCBI Gene Model | MGI Sequence Detail 34411 C57BL/6J ±  kb
    transcript NM_001403598 RefSeq | MGI Sequence Detail 6738 ZRU/MplStud  
    polypeptide Q6PDQ2 UniProt | EBI | MGI Sequence Detail 1915 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1196402, MGI:1889374, MGI:1924653, MGI:2384852
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 18
      Phenotypes 40
    • Earliest
      J:54004 Kim J, et al., Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999 Mar;10(3):345-55
    • Latest
      J:338019 Shi W, et al., Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1. Circ Res. 2023 Jun 23;133(1):48-67
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/19/2023
    MGI 6.22     		The Jackson Laboratory