Chd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chd4
chromodomain helicase DNA binding protein 4
MGI:1344380

42 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chd4^em1Flc/Chd4⁺ Not Specified	abnormal heart right ventricle morphology	J:338019
Chd4^em1Flc/Chd4^em1Flc C57BL/6J-Chd4^em1Flc	abnormal fetal cardiomyocyte physiology	J:338019
	abnormal heart echocardiography feature	J:338019
	abnormal heart morphology	J:338019
	abnormal heart ventricle morphology	J:338019
	abnormal myocardial fiber morphology	J:338019
	abnormal myocardial trabeculae morphology	J:338019
	abnormal skeletal muscle fiber morphology	J:338019
	abnormal Z line morphology	J:338019
	decreased heart rate	J:338019
	decreased skeletal muscle fiber number	J:338019
	decreased ventricle muscle contractility	J:338019
	increased cardiac jelly amount	J:338019
	increased fetal cardiomyocyte number	J:338019
	increased fetal cardiomyocyte proliferation	J:338019
	increased skeletal muscle fiber size	J:338019
	increased width of hypertrophic chondrocyte zone	J:338019
	neonatal lethality, incomplete penetrance	J:338019
	postnatal lethality, complete penetrance	J:338019
	thick interventricular septum	J:338019
	thick ventricular wall	J:338019
	thin myocardium compact layer	J:338019
	ventricular septal defect	J:338019
Chd4^{Gt(RRO120)Byg}/Chd4^{Gt(RRO120)Byg} B6.129P2-Chd4^{Gt(RRO120)Byg}	abnormal extraembryonic tissue physiology	J:224146
	absent blastocoele	J:224146
	embryonic lethality before implantation, complete penetrance	J:224146
	increased apoptosis	J:224146
Chd4^tm1.1Kge/Chd4^tm1.1Kge Tg(Lck-cre)1Cwi/0 involves: C57BL/6 * SJL	abnormal CD4-positive, alpha beta T cell morphology	J:109547
	abnormal T cell physiology	J:109547
	arrested T cell differentiation	J:109547
	decreased double-positive T cell number	J:109547
	increased CD8-positive, alpha-beta T cell number	J:109547
	lymph node hypoplasia	J:109547
	spleen hypoplasia	J:109547
Chd4^tm1.1Kge/Chd4^tm1.2Kge Tg(Lck-cre)1Cwi/0 involves: C57BL/6 * SJL	thymus hypoplasia	J:109547
Chd4^tm1.2Bh/Chd4^tm1.2Bh involves: 129P2/OlaHsd * C57BL/6 * CBA	embryonic lethality, complete penetrance	J:224146
Chd4^tm1.2Kge/Chd4^tm1.2Kge Tg(Lck-cre)1Cwi/0 involves: C57BL/6 * DBA/2 * SJL	abnormal cell cycle	J:109547
	abnormal T cell differentiation	J:109547
	decreased double-positive T cell number	J:109547
	decreased T cell proliferation	J:109547
	increased CD8-positive, alpha-beta T cell number	J:109547
	increased double-negative T cell number	J:109547
	thymus hypoplasia	J:109547
Chd4^{tm1b(EUCOMM)Wtsi}/Chd4^{tm1b(EUCOMM)Wtsi} C57BL/6N-Chd4^{tm1b(EUCOMM)Wtsi}/Bay	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23