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Arpc1b Gene Detail
Summary
  • Symbol
    Arpc1b
  • Name
    actin related protein 2/3 complex, subunit 1B
  • Synonyms
    L72, p41-ARC, SOP2Hs
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343142
    NCBI Gene: 11867
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145051066-145064996 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343142
 protein coding gene Chr5:145051025-145067515 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030356
 protein coding gene Chr5:150535998-150553907 (+)
A/J MGP_AJ_G0030325
 protein coding gene Chr5:144071092-144087504 (+)
AKR/J MGP_AKRJ_G0030257
 protein coding gene Chr5:148548628-148570358 (+)
BALB/cJ MGP_BALBcJ_G0030342
 protein coding gene Chr5:145325701-145342411 (+)
C3H/HeJ MGP_C3HHeJ_G0030053
 protein coding gene Chr5:149371129-149388277 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030787
 protein coding gene Chr5:156032760-156050319 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028008
 protein coding gene Chr5:137807409-137823967 (+)
CAST/EiJ MGP_CASTEiJ_G0029458
 protein coding gene Chr5:148938822-148957680 (+)
CBA/J MGP_CBAJ_G0030023
 protein coding gene Chr5:162471222-162488005 (+)
DBA/2J MGP_DBA2J_G0030173
 protein coding gene Chr5:143786255-143803038 (+)
FVB/NJ MGP_FVBNJ_G0030128
 protein coding gene Chr5:143021544-143038858 (+)
LP/J MGP_LPJ_G0030262
 protein coding gene Chr5:151121889-151140646 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030159
 protein coding gene Chr5:164772471-164796880 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030827
 protein coding gene Chr5:148452078-148471297 (+)
PWK/PhJ MGP_PWKPhJ_G0029173
 protein coding gene Chr5:142935085-142953299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029009
 protein coding gene Chr5:146200163-146218955 (+)
WSB/EiJ MGP_WSBEiJ_G0029533
 protein coding gene Chr5:149256350-149276369 (+)



Homology
more
  • Human Ortholog
    ARPC1B, actin related protein 2/3 complex subunit 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARPC1B, actin related protein 2/3 complex subunit 1B
  • Synonyms
    ARC41, IMD71, p40-ARC, p41-ARC, PLTEID
  • Links
    NCBI Gene ID: 10095
    UniProt: O15143

  • Chr Location
    7q22.1; chr7:99374249-99394816 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ARPC1B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal skin pigmentation and dermal fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    66
  • cDNA Data
    27
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11867 NCBI Gene Model | MGI Sequence Detail 13931 C57BL/6J ±  kb
    transcript NM_023142 RefSeq | MGI Sequence Detail 1555 C57BL/6  
    polypeptide Q9WV32 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000004309 actin-related protein 2/3 complex subunit 1B
      (term hierarchy)
    • PDB
      7AQK
    • InterPro Domains
      IPR017383 Actin-related protein 2/3 complex subunit 1
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9WV32 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1354729, MGI:2140731, MGI:2140737, MGI:2141167, MGI:2145918
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:29864 Mann M, et al., Identification of genes showing altered expression in preimplantation and early postimplantation parthenogenetic embryos. Dev Genet. 1995;17(3):223-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/07/2025
    MGI 6.24     		The Jackson Laboratory