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Klf3 Gene Detail
Summary
  • Symbol
    Klf3
  • Name
    Kruppel-like transcription factor 3 (basic)
  • Synonyms
    9930027G08Rik, Bklf, BKLF, Tef-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342773
    NCBI Gene: 16599
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:64960864-64990246 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342773
 protein coding gene Chr5:64960731-64990246 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029567
 protein coding gene Chr5:64405138-64434642 (+)
A/J MGP_AJ_G0029535
 protein coding gene Chr5:62006091-62036800 (+)
AKR/J MGP_AKRJ_G0029483
 protein coding gene Chr5:63958990-63990093 (+)
BALB/cJ MGP_BALBcJ_G0029544
 protein coding gene Chr5:62690564-62720809 (+)
C3H/HeJ MGP_C3HHeJ_G0029267
 protein coding gene Chr5:64320578-64351372 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029998
 protein coding gene Chr5:67071906-67103045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027238
 protein coding gene Chr5:58104222-58134186 (+)
CAST/EiJ MGP_CASTEiJ_G0028675
 protein coding gene Chr5:63403406-63435598 (+)
CBA/J MGP_CBAJ_G0029236
 protein coding gene Chr5:69225029-69256657 (+)
DBA/2J MGP_DBA2J_G0029382
 protein coding gene Chr5:62036653-62066362 (+)
FVB/NJ MGP_FVBNJ_G0029342
 protein coding gene Chr5:61213056-61243108 (+)
LP/J MGP_LPJ_G0029467
 protein coding gene Chr5:64873402-64902811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029370
 protein coding gene Chr5:72138292-72169492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030031
 protein coding gene Chr5:63635044-63665120 (+)
PWK/PhJ MGP_PWKPhJ_G0028399
 protein coding gene Chr5:61012085-61042182 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028233
 protein coding gene Chr5:62969898-63000611 (+)
WSB/EiJ MGP_WSBEiJ_G0028756
 protein coding gene Chr5:63867864-63901190 (+)



Homology
more
  • Human Ortholog
    KLF3, KLF transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF3, KLF transcription factor 3
  • Synonyms
    BKLF
  • Links
    NCBI Gene ID: 51274
    neXtProt AC: NX_P57682
    UniProt: P57682

  • Chr Location
    4p14; chr4:38664197-38701517 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 5 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced viability, body size and white adipose tissue. Mice homozygous for a gene trap allele exhibit cardiac defects, reduced body size and abnormal red blood cells. Mice heterozygous for an ENU-induced allele exhibit lethality with heart defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    141
  • cDNA Data
    16
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16599 NCBI Gene Model | MGI Sequence Detail 29383 C57BL/6J ±  kb
    transcript NR_165035 RefSeq | MGI Sequence Detail 5167 C57BL/6  
    polypeptide Q60980 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35910, MGI:107439, MGI:2141019, MGI:2441767
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 42
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory