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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Klf3
Kruppel-like transcription factor 3 (basic)
MGI:1342773
63 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Klf3Gt(CH0516)Wtsi/Klf3+
involves: 129P2/OlaHsd * C57BL/6 		normal mortality/aging J:206507
Klf3Gt(CH0516)Wtsi/Klf3Gt(CH0516)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood flow velocity J:206507
abnormal heart left ventricle morphology J:206507
normal cardiovascular system phenotype J:206507
decreased abdominal fat pad weight J:206507
decreased body weight J:206507
decreased mean systemic arterial blood pressure J:206507
normal hematopoietic system phenotype J:206507
increased brain weight J:206507
increased cardiac output J:206507
increased heart left atrium size J:206507
increased heart right atrium size J:206507
increased heart right ventricle size J:206507
increased heart weight J:206507
increased kidney weight J:206507
increased leukocyte cell number J:206507
increased liver weight J:206507
increased lung weight J:206507
increased red blood cell distribution width J:206507
increased spleen weight J:206507
preweaning lethality, incomplete penetrance J:206507
pulmonary valve regurgitation J:206507
reticulocytosis J:206507
tricuspid valve regurgitation J:206507
Klf3Gt(XS0187)Wtsi/Klf3+
involves: 129P2/OlaHsd * C57BL/6 		normal mortality/aging J:206507
Klf3Gt(XS0187)Wtsi/Klf3Gt(XS0187)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		aortic valve stenosis J:206507
normal cardiovascular system phenotype J:206507
decreased abdominal fat pad weight J:206507
decreased body weight J:206507
normal hematopoietic system phenotype J:206507
increased brain weight J:206507
increased cardiac output J:206507
increased heart right atrium size J:206507
increased heart right ventricle size J:206507
increased heart weight J:206507
increased kidney weight J:206507
increased leukocyte cell number J:206507
increased liver weight J:206507
increased lung weight J:206507
increased red blood cell distribution width J:206507
increased spleen weight J:206507
preweaning lethality, incomplete penetrance J:206507
pulmonary valve regurgitation J:206507
reticulocytosis J:206507
thick aortic valve cusps J:206507
tricuspid valve regurgitation J:206507
Klf3m1Cmhd/Klf3+
involves: BALB/cJ * C3H/HeJ * C57BL/6J 		abnormal blood flow velocity J:206507
Klf3m1Cmhd/Klf3+
involves: C3H/HeJ * C57BL/6J 		abnormal aortic valve cusp morphology J:206507
abnormal ascending aorta morphology J:206507
abnormal blood flow velocity J:206507
abnormal blood pressure regulation J:206507
abnormal heart left atrium morphology J:206507
abnormal heart left ventricle morphology J:206507
abnormal heart right atrium morphology J:206507
abnormal ventricle myocardium morphology J:206507
anemia J:206507
aortic valve stenosis J:206507
atrial septal defect J:206507
bicuspid aortic valve J:206507
cardiac hypertrophy J:206507
normal cardiovascular system phenotype J:206507
congestive heart failure J:206507
decreased abdominal fat pad weight J:206507
decreased body weight J:206507
decreased erythrocyte cell number J:206507
decreased hemoglobin content J:206507
decreased mean systemic arterial blood pressure J:206507
decreased percent body fat/body weight J:206507
decreased systemic arterial blood pressure J:206507
hematoma J:206507
hypervolemia J:206507
hypotension J:206507
increased atrioventricular cushion size J:206507
increased brain weight J:206507
increased cardiac muscle contractility J:206507
increased cardiac output J:206507
increased heart left atrium size J:206507
increased heart right atrium size J:206507
increased heart weight J:206507
increased kidney weight J:206507
increased oxygen consumption J:206507
increased spleen weight J:206507
lethality throughout fetal growth and development, incomplete penetrance J:206507
neonatal lethality, incomplete penetrance J:206507
premature death J:206507
reticulocytosis J:206507
thick aortic valve cusps J:206507
Klf3m1Cmhd/Klf3m1Cmhd
involves: C3H/HeJ * C57BL/6J 		abnormal interventricular septum morphology J:206507
abnormal ventricle myocardium morphology J:206507
atrial septal defect J:206507
lethality throughout fetal growth and development, complete penetrance J:206507
ventricular septal defect J:206507
Klf3tm1(cre/ERT2)Pzg/Klf3+
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:159099
Klf3tm1Merc/Klf3tm1Merc
FVB.129-Klf3tm1Merc 		abnormal cell differentiation J:137267
abnormal epididymal fat pad morphology J:137267
abnormal gonadal fat pad morphology J:137267
abnormal retroperitoneal fat pad morphology J:137267
decreased survivor rate J:137267
decreased total body fat amount J:137267
postnatal lethality, incomplete penetrance J:137267
slow postnatal weight gain J:137267
Klf3tm1Merc/Klf3tm1Merc
involves: 129 		infertility J:204573
preweaning lethality, incomplete penetrance J:204573
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory