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Hhip Gene Detail
Summary
  • Symbol
    Hhip
  • Name
    Hedgehog-interacting protein
  • Synonyms
    Hhip1, Hip, Hip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341847
    NCBI Gene: 15245
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Regulated by
    Rr219, Rr218, Rr695600 ... (4 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr8:80692480-80784635 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 37.95 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341847
 protein coding gene Chr8:80692480-80784637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033816
 protein coding gene Chr8:80663928-80757966 (-)
A/J MGP_AJ_G0033798
 protein coding gene Chr8:77444936-77537615 (-)
AKR/J MGP_AKRJ_G0033725
 protein coding gene Chr8:79754271-79848541 (-)
BALB/cJ MGP_BALBcJ_G0033792
 protein coding gene Chr8:77570126-77662793 (-)
C3H/HeJ MGP_C3HHeJ_G0033501
 protein coding gene Chr8:80402766-80497892 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034312
 protein coding gene Chr8:83752517-83853517 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031253
 protein coding gene Chr8:71485862-71576005 (-)
CAST/EiJ MGP_CASTEiJ_G0032832
 protein coding gene Chr8:79745287-79842526 (-)
CBA/J MGP_CBAJ_G0033480
 protein coding gene Chr8:86713611-86817347 (-)
DBA/2J MGP_DBA2J_G0033633
 protein coding gene Chr8:77152874-77248889 (-)
FVB/NJ MGP_FVBNJ_G0033578
 protein coding gene Chr8:76109960-76202346 (-)
LP/J MGP_LPJ_G0033723
 protein coding gene Chr8:80749908-80848188 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033621
 protein coding gene Chr8:89260475-89358891 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034329
 protein coding gene Chr8:79793138-79891079 (-)
PWK/PhJ MGP_PWKPhJ_G0032535
 protein coding gene Chr8:76418502-76510726 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032373
 protein coding gene Chr8:78587487-78683062 (-)
WSB/EiJ MGP_WSBEiJ_G0032945
 protein coding gene Chr8:80132785-80229000 (-)



Homology
more
  • Human Ortholog
    HHIP, hedgehog interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HHIP, hedgehog interacting protein
  • Synonyms
    HIP
  • Links
    NCBI Gene ID: 64399
    UniProt: Q96QV1

  • Chr Location
    4q31.21; chr4:144646156-144745271 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HHIP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele die shortly after birth due to respiratory failure, show defects in lung, spleen and pancreas morphogenesis, and exhibit small and disorganized pancreatic islets and reduced beta-cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1169
  • Tissues
    174
  • cDNA Data
    22
  • Literature Summary
    96
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064325 Ensembl Gene Model | MGI Sequence Detail 92156 C57BL/6J ±  kb
    transcript ENSMUST00000079038 Ensembl | MGI Sequence Detail 9074 Not Applicable  
    polypeptide ENSMUSP00000078047 Ensembl | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 23
      Primer pair 16
      Other 7

      Microarray probesets 7
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 96
      Gene Ontology 12
      Phenotypes 61
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:370996 Khouri-Farah N, et al., FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. Nat Neurosci. 2025 Aug 18;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory