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Eif4h Gene Detail
Summary
  • Symbol
    Eif4h
  • Name
    eukaryotic translation initiation factor 4H
  • Synonyms
    D5Ertd355e, E430026L18Rik, Eif4h, Wbscr1, Wscr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341822
    NCBI Gene: 22384
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134648726-134668263 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.71 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341822
 protein coding gene Chr5:134648575-134668344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030161
 protein coding gene Chr5:139048759-139069418 (-)
A/J MGP_AJ_G0030129
 protein coding gene Chr5:133139279-133160350 (-)
AKR/J MGP_AKRJ_G0030062
 protein coding gene Chr5:137455236-137475771 (-)
BALB/cJ MGP_BALBcJ_G0030139
 protein coding gene Chr5:134491156-134512487 (-)
C3H/HeJ MGP_C3HHeJ_G0029855
 protein coding gene Chr5:138006769-138027767 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030592
 protein coding gene Chr5:144276971-144297746 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027816
 protein coding gene Chr5:127419584-127439536 (-)
CAST/EiJ MGP_CASTEiJ_G0029264
 protein coding gene Chr5:137437279-137454989 (-)
CBA/J MGP_CBAJ_G0029825
 protein coding gene Chr5:149906956-149929703 (-)
DBA/2J MGP_DBA2J_G0029976
 protein coding gene Chr5:133033475-133053719 (-)
FVB/NJ MGP_FVBNJ_G0029931
 protein coding gene Chr5:132166234-132185920 (-)
LP/J MGP_LPJ_G0030064
 protein coding gene Chr5:139519876-139543190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029963
 protein coding gene Chr5:152958237-152979727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030632
 protein coding gene Chr5:137183428-137206876 (-)
PWK/PhJ MGP_PWKPhJ_G0028979
 protein coding gene Chr5:132064836-132085898 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028814
 protein coding gene Chr5:134759615-134782190 (-)
WSB/EiJ MGP_WSBEiJ_G0029338
 protein coding gene Chr5:137933926-137955454 (-)



Homology
more
  • Human Ortholog
    EIF4H, eukaryotic translation initiation factor 4H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4H, eukaryotic translation initiation factor 4H
  • Synonyms
    eIF-4H, WBSCR1, WSCR1
  • Links
    NCBI Gene ID: 7458
    neXtProt AC: NX_Q15056
    UniProt: Q15056

  • Chr Location
    7q11.23; chr7:74174231-74197122 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Eif4h mouse models; 1 with human EIF4H associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit growth defects and impaired cognitive behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    89
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22384 NCBI Gene Model | MGI Sequence Detail 19538 C57BL/6J ±  kb
    transcript NM_033561 RefSeq | MGI Sequence Detail 2503 ZRU/MplStud  
    polypeptide Q9WUK2 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 4
      cDNA 22
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1196428, MGI:2141045, MGI:2444028
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:55324 DeSilva U, et al., Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. Genome Res. 1999 May;9(5):428-36
    • Latest
      J:346070 Godoy-Corchuelo JM, et al., TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43. Neurobiol Dis. 2024 Feb 15;193:106437
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory