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Lipg Gene Detail
Summary
  • Symbol
    Lipg
  • Name
    lipase G, endothelial type
  • Synonyms
    3110013K01Rik, EL, endothelial lipase, mEDL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341803
    NCBI Gene: 16891
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:75072393-75094334 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.94 cM, cytoband E2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    679 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341803
 protein coding gene Chr18:75072393-75095380 (-)
129S1/SvImJ ENSMUSG00200026907
 protein coding gene Chr18:72292150-72314141 (-)
A/J ENSMUSG00195004734
 protein coding gene Chr18:72355318-72377268 (-)
AKR/J ENSMUSG00220016829
 protein coding gene Chr18:72277089-72299094 (-)
BALB/cJ ENSMUSG00180012850
 protein coding gene Chr18:72931867-72953808 (-)
C3H/HeJ ENSMUSG00175011614
 protein coding gene Chr18:72486095-72508031 (-)
C57BL/6NJ ENSMUSG00215018190
 protein coding gene Chr18:71835778-71857720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022403
 protein coding gene Chr18:71364045-71386811 (-)
CAST/EiJ ENSTCUG00005025974
 protein coding gene Chr18:71398019-71420044 (-)
CBA/J ENSMUSG00210033061
 protein coding gene Chr18:72443554-72465491 (-)
DBA/2J ENSMUSG00185011307
 protein coding gene Chr18:72349738-72371678 (-)
FVB/NJ ENSMUSG00205013594
 protein coding gene Chr18:71959585-71981536 (-)
JF1/MsJ ENSUMUG00000023632
 protein coding gene Chr18:72259475-72281424 (-)
LP/J ENSMUSG00230013211
 protein coding gene Chr18:74407801-74429796 (-)
NOD/ShiLtJ ENSMUSG00190021402
 protein coding gene Chr18:72100812-72122746 (-)
NZO/HlLtJ ENSMUSG00225033808
 protein coding gene Chr18:74263366-74285323 (-)
PWK/PhJ ENSLUMG00010006246
 protein coding gene Chr18:72670108-72692061 (-)
SPRET/EiJ ENSMSPG00010008134
 protein coding gene Chr18:72919227-72941606 (-)
WSB/EiJ ENSIUOG00005007142
 protein coding gene Chr18:71887902-71909889 (-)



Homology
more
  • Human Ortholog
    LIPG, lipase G, endothelial type
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPG, lipase G, endothelial type
  • Synonyms
    EDL, EL, PRO719
  • Links
    NCBI Gene ID: 9388
    UniProt: Q9Y5X9

  • Chr Location
    18q21.1; chr18:49560699-49599185 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human LIPG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased circulating total cholesterol and HDL as well as decreased monocyte binding to vascular endothelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    992
  • Tissues
    158
  • cDNA Data
    21
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053846 Ensembl Gene Model | MGI Sequence Detail 21942 C57BL/6J ±  kb
    transcript ENSMUST00000066532 Ensembl | MGI Sequence Detail 3787 Not Applicable  
    polypeptide ENSMUSP00000066536 Ensembl | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920366
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:54918 Hirata K, et al., Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem. 1999 May 14;274(20):14170-5
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory