Parp2 MGI Mouse Gene Detail - MGI:1341112 - poly (ADP-ribose) polymerase family, member 2

Symbol

Parp2
Name

poly (ADP-ribose) polymerase family, member 2
Synonyms

Adprt2, Adprtl2, Aspartl2, C78626, PARP-2

Feature Type

protein coding gene
IDs

MGI:1341112
NCBI Gene: 11546
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:51045347-51058758 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.25 cM, cytoband C1
Mapping Data

4 experiments

SNPs within 2kb

150 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341112	protein coding gene	Chr14:51045298-51058758 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021258	protein coding gene	Chr14:44758756-44771663 (+)
A/J	MGP_AJ_G0021212	protein coding gene	Chr14:43422267-43436514 (+)
AKR/J	MGP_AKRJ_G0021188	protein coding gene	Chr14:45051567-45065974 (+)
BALB/cJ	MGP_BALBcJ_G0021215	protein coding gene	Chr14:43536045-43549158 (+)
C3H/HeJ	MGP_C3HHeJ_G0020997	protein coding gene	Chr14:44876356-44893074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021651	protein coding gene	Chr14:46571547-46598568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019204	protein coding gene	Chr14:42761892-42776614 (+)
CAST/EiJ	MGP_CASTEiJ_G0020521	protein coding gene	Chr14:41940193-41955365 (+)
CBA/J	MGP_CBAJ_G0020964	protein coding gene	Chr14:48067775-48083944 (+)
DBA/2J	MGP_DBA2J_G0021088	protein coding gene	Chr14:43318643-43332122 (+)
FVB/NJ	MGP_FVBNJ_G0021069	protein coding gene	Chr14:42945239-42959273 (+)
LP/J	MGP_LPJ_G0021156	protein coding gene	Chr14:45037421-45052032 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021097	protein coding gene	Chr14:47544128-47559383 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021681	protein coding gene	Chr14:44546842-44563567 (+)
PWK/PhJ	MGP_PWKPhJ_G0020271	protein coding gene	Chr14:40217085-40230423 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020096	protein coding gene	Chr14:40706335-40719309 (+)
WSB/EiJ	MGP_WSBEiJ_G0020574	protein coding gene	Chr14:44739534-44752675 (+)

Human Ortholog

PARP2, poly(ADP-ribose) polymerase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP2, poly(ADP-ribose) polymerase 2
Synonyms

ADPRT2, ADPRTL2, ADPRTL3, ARTD2, pADPRT-2, PARP-2
Links

HGNC:272

NCBI Gene ID: 10038

neXtProt AC: NX_Q9UGN5

UniProt: Q9UGN5
Chr Location

14q11.2; chr14:20343615-20357904 (+) GRCh38

MGI Vertebrate Homology

Parp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARP2
Gene Tree

Parp2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

21
Targeted

3
Genomic Mutations

1 involving Parp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury.

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All GO Annotations

58
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

38
cDNA Data

43
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp2

ZFIN parp2

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All Sequences

55
RefSeq

12
UniProt

2
CCDS

CCDS27025.1

Ensembl

ENSMUSG00000036023 (Evidence)
NCBI Gene

11546

			Length	Strain/Species	Flank
genomic	11546	NCBI Gene Model \| MGI Sequence Detail	13412	C57BL/6J	± kb
transcript	NR_185484	RefSeq \| MGI Sequence Detail	2332	ZRU/MplStud
polypeptide	O88554	UniProt \| EBI \| MGI Sequence Detail	559	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012296 poly [ADP-ribose] polymerase 2

(term hierarchy)
PDB

1GS0
EC

2.4.2.-, 2.4.2.30
InterPro Domains

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR004102 Poly(ADP-ribose) polymerase, regulatory domain

IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamily

IPR008893 WGR domain

IPR036930 WGR domain superfamily

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All nucleic 47

Genomic 1

cDNA 43

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1353643

Summaries

All 79

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 34
Earliest

J:54433 Berghammer H, et al., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 1999 Apr 23;449(2-3):259-63
Latest

J:346121 Shu J, et al., PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int J Biol Sci. 2024;20(5):1602-1616

TSS for Parp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125369	Chr14:51044947-51044968 (+)	-389 bp
Tssr125370	Chr14:51045372-51045399 (+)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23