Parp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Parp2
poly (ADP-ribose) polymerase family, member 2
MGI:1341112

34 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Parp2^{em1(IMPC)Ccpcz}/Parp2^{em1(IMPC)Ccpcz} C57BL/6NCrl-Parp2^{em1(IMPC)Ccpcz}/Ccpcz	abnormal eye morphology	J:211773
	abnormal heart morphology	J:211773
	abnormal QT variability	J:211773
	abnormal sinus arrhythmia	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	cardiovascular system phenotype	J:211773
	decreased circulating iron level	J:211773
	decreased heart rate	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	increased fasting circulating glucose level	J:211773
	increased heart left ventricle size	J:211773
	increased spleen weight	J:211773
	prolonged QT interval	J:211773
	prolonged RR interval	J:211773
Parp2^tm1.1Shzh/Parp2^tm1.1Shzh Not Specified	anemia	J:358182
	decreased DNA replication	J:358182
	decreased erythroblast number	J:358182
	embryonic lethality during organogenesis, complete penetrance	J:358182
	impaired hematopoiesis	J:358182
	liver hypoplasia	J:358182
	pale liver	J:358182
	spontaneous chromosome breakage	J:358182
Parp2^tm1Jmdm/Parp2^tm1Jmdm involves: 129S2/SvPas * C57BL/6	abnormal cell cycle checkpoint function	J:83371
	normal cellular phenotype	J:83371
	elevated level of mitotic sister chromatid exchange	J:83371
	impaired DNA repair	J:83371
	increased cellular sensitivity to gamma-irradiation induced cell death	J:83371
	increased mortality induced by gamma-irradiation	J:83371
	induced chromosome breakage	J:83371
	normal neoplasm	J:83371

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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