Parp2^tm1.1Shzh
Targeted Allele Detail

Summary

• Symbol: Parp2^tm1.1Shzh
• Name: poly (ADP-ribose) polymerase family, member 2; targeted mutation 1.1, Shan Zha
• MGI ID: MGI:8282691
• Synonyms: Parp2^EA
• Gene: Parp2 Location: Chr14:51045347-51058758 bp, + strand Genetic Position: Chr14, 26.25 cM, cytoband C1
• Alliance: Parp2^tm1.1Shzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Glutamic acid codon 534 (GAG) in exon 16 was changed to alanine (GCC) (p.E534A) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 13. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation renders the encoded protein catalytically inactive. (J:358182)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp2 Mutation: 29 strains or lines available

References

• Original: J:358182 Lin X, et al., Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7
• All: 1 reference(s)