Phenotypes associated with this allele

• Allele Symbol: Parp2^tm1.1Shzh
• Allele Name: targeted mutation 1.1, Shan Zha
• Allele ID: MGI:8282691
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Parp2^tm1.1Shzh/Parp2^tm1.1Shzh	Not Specified	MGI:8282754

Genotype
MGI:8282754

hm1

• Allelic Composition: Parp2^tm1.1Shzh/Parp2^tm1.1Shzh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased DNA replication ( J:358182 )

• impaired DNA replication in erythroblasts of E13.5 embryos

spontaneous chromosome breakage ( J:358182 )

• replication-dependent genomic instability in erythroblasts of E13.5 embryos

hematopoietic system

anemia ( J:358182 )

• 90% reduction in TER119+ erythrocytes in livers of E13.5 embryos

impaired hematopoiesis ( J:358182 )

• 90% reduction in TER119+ erythrocytes in livers of E13.5 embryos

decreased erythroblast number ( J:358182 )

• 7-10-fold reduction in livers of E13.5 embryos

• increased erythroblast apoptosis

homeostasis/metabolism

decreased DNA replication ( J:358182 )

• impaired DNA replication in erythroblasts of E13.5 embryos

liver/biliary system

liver hypoplasia ( J:358182 )

• 70% reduction in cellularity in E13.5 embryos

• 90% reduction in TER119+ erythrocytes and 50% reduction of B220+ B cells

pale liver ( J:358182 )

• in E13.5 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:358182 )

• no homozygous pups born