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Rnf7 Gene Detail
Summary
  • Symbol
    Rnf7
  • Name
    ring finger protein 7
  • Synonyms
    Rbx2, Sag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337096
    NCBI Gene: 19823
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:96352990-96360728 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.63 cM, cytoband D2.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337096
 protein coding gene Chr9:96352990-96360728 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035144
 protein coding gene Chr9:97669202-97676987 (-)
A/J MGP_AJ_G0035125
 protein coding gene Chr9:94255178-94264911 (-)
AKR/J MGP_AKRJ_G0035057
 protein coding gene Chr9:96565441-96573050 (-)
BALB/cJ MGP_BALBcJ_G0035118
 protein coding gene Chr9:93942281-93950560 (-)
C3H/HeJ MGP_C3HHeJ_G0034828
 protein coding gene Chr9:96964403-96972557 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035638
 protein coding gene Chr9:100466492-100473315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013935
 protein coding gene Chr1:5042394-5043488 (-)
CAST/EiJ MGP_CASTEiJ_G0034140
 protein coding gene Chr9:96741482-96747966 (-)
CBA/J MGP_CBAJ_G0034796
 protein coding gene Chr9:103955147-103965550 (-)
DBA/2J MGP_DBA2J_G0034958
 protein coding gene Chr9:93780037-93787414 (-)
FVB/NJ MGP_FVBNJ_G0034906
 protein coding gene Chr9:92629211-92638217 (-)
LP/J MGP_LPJ_G0035037
 protein coding gene Chr9:97936974-97945228 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034945
 protein coding gene Chr9:105959142-105968351 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035660
 protein coding gene Chr9:96788233-96796195 (-)
PWK/PhJ MGP_PWKPhJ_G0033847
 protein coding gene Chr9:93954606-93963407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033682
 protein coding gene Chr9:96843954-96854059 (-)
WSB/EiJ MGP_WSBEiJ_G0034260
 protein coding gene Chr9:96655058-96662312 (-)



Homology
more
  • Human Ortholog
    RNF7, ring finger protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF7, ring finger protein 7
  • Synonyms
    CKBBP1, rbx2, ROC2, SAG
  • Links
    NCBI Gene ID: 9616
    neXtProt AC: NX_Q9UBF6
    UniProt: Q9UBF6

  • Chr Location
    3q23; chr3:141738249-141747560 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with defects in angiogenesis, widespread apoptosis, impaired cell cycle progression of neuronal precursors and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19823 NCBI Gene Model | MGI Sequence Detail 7739 C57BL/6J ±  kb
    transcript NM_011279 RefSeq | MGI Sequence Detail 1232 C57BL/6  
    polypeptide Q9WTZ1 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
      6V9I
    • InterPro Domains
      IPR024991 Anaphase-promoting complex subunit 11, RING-H2 finger
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR024766 Zinc finger, RING-H2-type
      IPR001841 Zinc finger, RING-type
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:53898 Duan H, et al., SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol. 1999 Apr;19(4):3145-55
    • Latest
      J:332394 Tan M, et al., The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Rep. 2022 Dec 20;41(12):111837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory