Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable NEDD8 ligase activity; cullin family protein binding activity; and ubiquitin protein ligase activity. Acts upstream of or within several processes, including apoptotic mitochondrial changes; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7).