About   Help   FAQ
Mapkapk5 Gene Detail
Summary
  • Symbol
    Mapkapk5
  • Name
    MAP kinase-activated protein kinase 5
  • Synonyms
    MK5, PRAK
Location &
Maps
more
  • Sequence Map
    Chr5:121663114-121683955 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.84 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333110
 protein coding gene Chr5:121663101-121683968 (-)
129S1/SvImJ ENSMUSG00200024816
 protein coding gene Chr5:115402960-115423868 (-)
A/J ENSMUSG00195009830
 protein coding gene Chr5:114924236-114945130 (-)
AKR/J ENSMUSG00220040869
 protein coding gene Chr5:114424382-114445268 (-)
BALB/cJ ENSMUSG00180035138
 protein coding gene Chr5:115038790-115059697 (-)
C3H/HeJ ENSMUSG00175025710
 protein coding gene Chr5:117044062-117065245 (-)
C57BL/6NJ ENSMUSG00215028032
 protein coding gene Chr5:115070111-115090978 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027687
 protein coding gene Chr5:114543360-114563207 (-)
CAST/EiJ ENSTCUG00005030618
 protein coding gene Chr5:114313281-114333920 (-)
CBA/J ENSMUSG00210006189
 protein coding gene Chr5:115794916-115816087 (-)
DBA/2J ENSMUSG00185048830
 protein coding gene Chr5:118846409-118867274 (-)
FVB/NJ ENSMUSG00205035213
 protein coding gene Chr5:114699636-114720803 (-)
JF1/MsJ ENSUMUG00000051036
 protein coding gene Chr5:121699220-121719828 (-)
LP/J ENSMUSG00230041531
 protein coding gene Chr5:122925068-122945974 (-)
NOD/ShiLtJ ENSMUSG00190023838
 protein coding gene Chr5:114735679-114756844 (-)
NZO/HlLtJ ENSMUSG00225014145
 protein coding gene Chr5:130602975-130624138 (-)
PWK/PhJ ENSLUMG00010035459
 protein coding gene Chr5:113610829-113631429 (-)
SPRET/EiJ ENSMSPG00010038422
 protein coding gene Chr5:116919365-116939443 (-)
WSB/EiJ ENSIUOG00005017746
 protein coding gene Chr5:117419118-117439765 (-)



Homology
more
  • Human Ortholog
    MAPKAPK5, MAPK activated protein kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPKAPK5, MAPK activated protein kinase 5
  • Synonyms
    MAPKAP-K5, MK-5, MK5, NCFD, PRAK
  • Links
    NCBI Gene ID: 8550
    UniProt: Q8IW41

  • Chr Location
    12q24.12-q24.13; chr12:111842013-111902222 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    16
  • cDNA Data
    50
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17165 NCBI Gene Model | MGI Sequence Detail 20842 C57BL/6J ±  kb
transcript NM_010765 RefSeq | MGI Sequence Detail 2229 Not Specified  
polypeptide O54992 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010167 MAP kinase-activated protein kinase 5
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR050205 Calcium-dependent Serine/Threonine Protein Kinases
    IPR027442 MAP kinase activated protein kinase, C-terminal
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
  • GlyGen
    O54992 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 52
    cDNA 51
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 2
    Gene Ontology 16
    Phenotypes 27
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory