Fmo1 Gene Detail

Summary

• Symbol
  Fmo1
• Name
  flavin containing monooxygenase 1

• Feature Type
  protein coding gene
• IDs
  MGI:1310002
  NCBI Gene: 14261
• Alliance
  gene page
• Transcription Start Sites
  18 TSS
• Candidate for QTL
  8 QTL

Location &
Maps

• Sequence Map
  Chr1:162657130-162694170 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 70.34 cM, cytoband H1
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1132 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1310002	protein coding gene	Chr1:162657130-162694179 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016665	protein coding gene	Chr1:168184760-168228422 (-)
A/J	MGP_AJ_G0016646	protein coding gene	Chr1:161341855-161372275 (-)
AKR/J	MGP_AKRJ_G0016612	protein coding gene	Chr1:166218027-166259980 (-)
BALB/cJ	MGP_BALBcJ_G0016607	protein coding gene	Chr1:161850726-161880793 (-)
C3H/HeJ	MGP_C3HHeJ_G0016431	protein coding gene	Chr1:166424090-166457776 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017068	protein coding gene	Chr1:173831893-173869221 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014777	protein coding gene	Chr1:153374625-153407427 (-)
CAST/EiJ	MGP_CASTEiJ_G0016011	protein coding gene	Chr1:166075396-166109792 (-)
CBA/J	MGP_CBAJ_G0016406	protein coding gene	Chr1:180036011-180079235 (-)
DBA/2J	MGP_DBA2J_G0016512	protein coding gene	Chr1:160266903-160297173 (-)
FVB/NJ	MGP_FVBNJ_G0016510	protein coding gene	Chr1:158704401-158735372 (-)
LP/J	MGP_LPJ_G0016583	protein coding gene	Chr1:169293603-169326394 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016535	protein coding gene	Chr1:187542038-187575249 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017104	protein coding gene	Chr1:166050536-166084119 (-)
PWK/PhJ	MGP_PWKPhJ_G0015797	protein coding gene	Chr1:159454130-159484425 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015584	protein coding gene	Chr1:164941607-164975517 (-)
WSB/EiJ	MGP_WSBEiJ_G0016073	protein coding gene	Chr1:166234298-166264136 (-)

Homology

• Human Ortholog
  FMO1, flavin containing dimethylaniline monoxygenase 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FMO1, flavin containing dimethylaniline monoxygenase 1
  
• Links
  HGNC:3769

  NCBI Gene ID: 2326

  UniProt: Q01740

  
  
• Chr Location
  1q24.3; chr1:171248471-171285978 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fmo1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: FMO1
• Protein SuperFamily
  FMO
• Gene Tree
  Fmo1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 2 alleles in 2 genetic backgrounds
  12 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  2
• Endonuclease-mediated
  4
• Targeted
  2
• Genomic Mutations
  3 involving Fmo1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  40 strains or lines available

Mice homozygous for a null mutation display decreased dopaminerginc neuron numbers and increased cytokine levels in the substania nigra.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  15
• GO References
  5

Expression

• Assay Results
  726
• Tissues
  18
• cDNA Data
  115
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fmo1

Sequences &
Gene Models

• All Sequences
  62
• RefSeq
  18
• UniProt
  5
• CCDS
  CCDS15424.1, CCDS87907.1

• Ensembl
  ENSMUSG00000040181 (Evidence)
• NCBI Gene
  14261

Representative Sequences			Length	Strain/Species
genomic	14261	NCBI Gene Model | MGI Sequence Detail	37041	C57BL/6J
transcript	NM_010231	RefSeq | MGI Sequence Detail	2379	ZRU/MplStud
polypeptide	P50285	UniProt | EBI | MGI Sequence Detail	532	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000007574 flavin-containing monooxygenase 1
  (term hierarchy)
• EC
  1.-.-.-, 1.14.13.148, 1.14.13.8
• InterPro Domains
  IPR036188 FAD/NAD(P)-binding domain superfamily
  IPR050346 Flavin-containing Monooxygenases
  IPR000960 Flavin monooxygenase FMO
  IPR002253 Flavin monooxygenase (FMO) 1
  IPR020946 Flavin monooxygenase-like
• GlyGen
  P50285 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 116

  cDNA 116

  
  

  Microarray probesets 3

References

• Summaries
  All 39

  Developmental Gene Expression 4

  Gene Ontology 5

  Phenotypes 12
• Earliest
  J:28615 Falls JG, et al., Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. J Biochem Toxicol. 1995 Jun;10(3):171-7
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Fmo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14678	Chr1:162694071-162694185 (-)	42 bp
Tssr14677	Chr1:162694052-162694070 (-)	109 bp
Tssr14676	Chr1:162694032-162694037 (-)	135 bp
Tssr14675	Chr1:162694009-162694020 (-)	155 bp
Tssr14674	Chr1:162693994-162694001 (-)	172 bp
Tssr14673	Chr1:162693928-162693971 (-)	220 bp
Tssr14672	Chr1:162687683-162687695 (-)	6,481 bp
Tssr14671	Chr1:162687666-162687677 (-)	6,498 bp
Tssr14670	Chr1:162687648-162687663 (-)	6,514 bp
Tssr14669	Chr1:162687629-162687646 (-)	6,532 bp
Tssr14668	Chr1:162687553-162687563 (-)	6,612 bp
Tssr14667	Chr1:162687488-162687542 (-)	6,655 bp
Tssr14666	Chr1:162687441-162687452 (-)	6,723 bp
Tssr14665	Chr1:162687400-162687411 (-)	6,764 bp
Tssr14664	Chr1:162687380-162687394 (-)	6,783 bp
Tssr14663	Chr1:162687253-162687304 (-)	6,891 bp
Tssr14662	Chr1:162687125-162687141 (-)	7,037 bp
Tssr14661	Chr1:162661872-162661876 (-)	32,296 bp

Fmo1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Insq2	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Insq6	Chr1, 38.01 cM	Chr1:73726922-73727077	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Nidd6	Chr1, 65.11 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq2	Chr1, 6.50 cM	Chr1:20941620-20941887	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq7	Chr1, 33.31 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Obq9	Chr1, 74.68 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Wt6q1	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.
Wt6q2	Chr1, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.

*cM position of peak correlated region/marker