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Ppp1r12a Gene Detail
Summary
  • Symbol
    Ppp1r12a
  • Name
    protein phosphatase 1, regulatory subunit 12A
  • Synonyms
    1200015F06Rik, 5730577I22Rik, D10Ertd625e, Mypt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309528
    NCBI Gene: 17931
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107997913-108115846 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 56.33 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309528
 protein coding gene Chr10:107997913-108120336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017712
 protein coding gene Chr10:110400250-110518667 (+)
A/J MGP_AJ_G0017689
 protein coding gene Chr10:106243189-106359718 (+)
AKR/J MGP_AKRJ_G0017651
 protein coding gene Chr10:109328736-109445295 (+)
BALB/cJ MGP_BALBcJ_G0017653
 protein coding gene Chr10:106626310-106743200 (+)
C3H/HeJ MGP_C3HHeJ_G0017478
 protein coding gene Chr10:109448398-109568349 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018110
 protein coding gene Chr10:114246022-114361034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015789
 protein coding gene Chr10:101157434-101270367 (+)
CAST/EiJ MGP_CASTEiJ_G0017039
 protein coding gene Chr10:109554804-109675584 (+)
CBA/J MGP_CBAJ_G0017447
 protein coding gene Chr10:118680456-118800327 (+)
DBA/2J MGP_DBA2J_G0017552
 protein coding gene Chr10:105383209-105503772 (+)
FVB/NJ MGP_FVBNJ_G0017546
 protein coding gene Chr10:104380021-104494974 (+)
LP/J MGP_LPJ_G0017626
 protein coding gene Chr10:111022409-111145611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017575
 protein coding gene Chr10:121241929-121400121 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018148
 protein coding gene Chr10:109335512-109453037 (+)
PWK/PhJ MGP_PWKPhJ_G0016821
 protein coding gene Chr10:105454307-105579217 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016611
 protein coding gene Chr10:108106681-108224021 (+)
WSB/EiJ MGP_WSBEiJ_G0017099
 protein coding gene Chr10:109460176-109583492 (+)



Homology
more
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
  • Synonyms
    GUBS, M130, MBS, MYPT1
  • Links
    NCBI Gene ID: 4659
    neXtProt AC: NX_O14974
    UniProt: O14974

  • Chr Location
    12q21.2-q21.31; chr12:79773563-79935460 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before E7.5. Mice homozygous for a smooth muscle specific conditional knockout exhibit altered intestinal smooth muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    16
  • cDNA Data
    23
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17931 NCBI Gene Model | MGI Sequence Detail 117934 C57BL/6J ±  kb
    transcript NM_027892 RefSeq | MGI Sequence Detail 6115 ZRU/MplStud  
    polypeptide Q9DBR7 UniProt | EBI | MGI Sequence Detail 1029 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013107 protein phosphatase 1 regulatory subunit 12A
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR031775 cGMP-dependent protein kinase, interacting domain
      IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1289205, MGI:1917922, MGI:1918986, MGI:2143509, MGI:2143782
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 16
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333966 Nagaoka T, et al., Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium. Sci Rep. 2023 Mar 8;13(1):3905
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory