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Crygs Gene Detail
Summary
  • Symbol
    Crygs
  • Name
    crystallin, gamma S
  • Synonyms
    Opj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298216
    NCBI Gene: 12970
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22623953-22630160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.66 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298216
 protein coding gene Chr16:22623953-22630327 (-)
129S1/SvImJ ENSMUSG00200043599
 protein coding gene Chr16:19623835-19630211 (-)
A/J ENSMUSG00195029567
 protein coding gene Chr16:19182160-19188540 (-)
AKR/J ENSMUSG00220039377
 protein coding gene Chr16:19501583-19507959 (-)
BALB/cJ ENSMUSG00180034984
 protein coding gene Chr16:19422755-19429132 (-)
C3H/HeJ ENSMUSG00175040508
 protein coding gene Chr16:19567697-19574072 (-)
C57BL/6NJ ENSMUSG00215038649
 protein coding gene Chr16:19294915-19301288 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020605
 protein coding gene Chr16:20037404-20043351 (-)
CAST/EiJ ENSTCUG00005044621
 protein coding gene Chr16:19910219-19916626 (-)
CBA/J ENSMUSG00210037778
 protein coding gene Chr16:19589412-19595786 (-)
DBA/2J ENSMUSG00185028359
 protein coding gene Chr16:19528168-19534543 (-)
FVB/NJ ENSMUSG00205033943
 protein coding gene Chr16:19524089-19530463 (-)
JF1/MsJ ENSUMUG00000043955
 protein coding gene Chr16:19759508-19765846 (-)
LP/J ENSMUSG00230032543
 protein coding gene Chr16:22107255-22113630 (-)
NOD/ShiLtJ ENSMUSG00190029119
 protein coding gene Chr16:19669616-19675991 (-)
NZO/HlLtJ ENSMUSG00225035966
 protein coding gene Chr16:25358343-25364718 (-)
PWK/PhJ ENSLUMG00010039482
 protein coding gene Chr16:19582691-19589036 (-)
SPRET/EiJ ENSMSPG00010046412
 protein coding gene Chr16:19456559-19462904 (-)
WSB/EiJ ENSIUOG00005040834
 protein coding gene Chr16:19763937-19770310 (-)



Homology
more
  • Human Ortholog
    CRYGS, crystallin gamma S
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGS, crystallin gamma S
  • Synonyms
    CRYG8, CTRCT20
  • Links
    NCBI Gene ID: 1427
    UniProt: P22914

  • Chr Location
    3q27.3; chr3:186538441-186546702 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crygs mouse models; 1 with human CRYGS associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene can cause cataracts and/or disrupted lens fiber cell morphology and organization. Aging mice homozygous for a knock-out allele do not develop cataracts but show focusing defects associated with inefficient clearance of cellular organelles and altered actin distribution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    7
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12970 NCBI Gene Model | MGI Sequence Detail 6208 C57BL/6J ±  kb
    transcript NM_009967 RefSeq | MGI Sequence Detail 708 ZRU/MplStud  
    polypeptide O35486 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory