Phenotypes Associated with This Genotype

Genotype
MGI:3584122

• Allelic Composition: Crygs^Opj/Crygs^Opj
• Genetic Background: involves: 102 * C3H/He * T STOCK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Progressive cataract development in Crygs^Opj/Crygs⁺ and Crygs^Opj/Crygs^Opj mice

vision/eye

abnormal lens morphology ( J:68109 )

• tangled fibrous masses are seen in the lenses

abnormal lens fiber morphology ( J:68109 )

• swelling and disorganization in the cortical fibers is seen at early stages

• a sharp, distorted boundary between the outer cortical fiber layer and the inner layer is seen

• fiber maturation is disrupted, with loss of nuclei not occuring in a timely fashion, leaving particles in the inner layers of fiber cells

total cataract ( J:34877 , J:68109 )

• total opacity (J:34877)

• progressive with age and more severe than in heterozygote (J:68109)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 20 multiple types		DOID:0110240	OMIM:116100	J:34877 , J:68109