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Kcnn4 Gene Detail
Summary
  • Symbol
    Kcnn4
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
  • Synonyms
    IK1, IKCa1, KCa3.1, mIKCa1, SK4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277957
    NCBI Gene: 16534
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24069251-24084637 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 10.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277957
 protein coding gene Chr7:24069251-24086115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031826
 protein coding gene Chr7:22686055-22703149 (+)
A/J MGP_AJ_G0031805
 protein coding gene Chr7:22169497-22185162 (+)
AKR/J MGP_AKRJ_G0031734
 protein coding gene Chr7:22669836-22685096 (+)
BALB/cJ MGP_BALBcJ_G0031811
 protein coding gene Chr7:22377102-22392903 (+)
C3H/HeJ MGP_C3HHeJ_G0031531
 protein coding gene Chr7:23074445-23094278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032274
 protein coding gene Chr7:23432277-23450221 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029332
 protein coding gene Chr7:23642750-23658574 (+)
CAST/EiJ MGP_CASTEiJ_G0030872
 protein coding gene Chr7:16538667-16558155 (+)
CBA/J MGP_CBAJ_G0031496
 protein coding gene Chr7:24313556-24334881 (+)
DBA/2J MGP_DBA2J_G0031650
 protein coding gene Chr7:22086650-22102689 (+)
FVB/NJ MGP_FVBNJ_G0031603
 protein coding gene Chr7:22040660-22057258 (+)
LP/J MGP_LPJ_G0031729
 protein coding gene Chr7:23037525-23057271 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031640
 protein coding gene Chr7:24096167-24114383 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032306
 protein coding gene Chr7:22379066-22397040 (+)
PWK/PhJ MGP_PWKPhJ_G0030596
 protein coding gene Chr7:16970071-16990334 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030426
 protein coding gene Chr7:13715212-13732203 (+)
WSB/EiJ MGP_WSBEiJ_G0030975
 protein coding gene Chr7:22503775-22521643 (+)



Homology
more
  • Human Ortholog
    KCNN4, potassium calcium-activated channel subfamily N member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNN4, potassium calcium-activated channel subfamily N member 4
  • Synonyms
    DHS2, hIKCa1, hKCa4, hSK4, IK, IK1, IKCA1, KCa3.1, KCA4, SK4
  • Links
    NCBI Gene ID: 3783
    neXtProt AC: NX_O15554
    UniProt: O15554

  • Chr Location
    19q13.31; chr19:43766533-43782139 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human KCNN4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null male mice have increased parotid gland weight and both sexes have impaired volume regulation in erythrocytes and T lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    136
  • cDNA Data
    241
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16534 NCBI Gene Model | MGI Sequence Detail 15387 C57BL/6J ±  kb
    transcript NM_001163510 RefSeq | MGI Sequence Detail 1973 C57BL/6  
    polypeptide O89109 UniProt | EBI | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
      (term hierarchy)
    • InterPro Domains
      IPR004178 Calmodulin-binding domain
      IPR015449 Potassium channel, calcium-activated, SK
      IPR013099 Potassium channel domain
      IPR036122 SK, calmodulin-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 246
      cDNA 241
      Primer pair 3
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 49
    • Earliest
      J:49276 Vandorpe DH, et al., cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21;273(34):21542-53
    • Latest
      J:286787 Lozano-Gerona J, et al., Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS One. 2020;15(3):e0222619
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/17/2023
    MGI 6.22     		The Jackson Laboratory