Rpap3 MGI Mouse Gene Detail - MGI:1277218 - RNA polymerase II associated protein 3

Symbol

Rpap3
Name

RNA polymerase II associated protein 3
Synonyms

2310042P20Rik, D15Ertd682e

Feature Type

protein coding gene
IDs

MGI:1277218
NCBI Gene: 71919
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:97572978-97603706 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 53.54 cM, cytoband F2
Mapping Data

4 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277218	protein coding gene	Chr15:97572978-97603746 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022276	protein coding gene	Chr15:99344276-99375777 (-)
A/J	MGP_AJ_G0022235	protein coding gene	Chr15:95414119-95445434 (-)
AKR/J	MGP_AKRJ_G0022210	protein coding gene	Chr15:98292478-98324845 (-)
BALB/cJ	MGP_BALBcJ_G0022241	protein coding gene	Chr15:95639410-95671181 (-)
C3H/HeJ	MGP_C3HHeJ_G0022011	protein coding gene	Chr15:98371725-98402316 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022686	protein coding gene	Chr15:103009133-103043589 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020212	protein coding gene	Chr15:91361202-91393203 (-)
CAST/EiJ	MGP_CASTEiJ_G0021533	protein coding gene	Chr15:99245430-99276679 (-)
CBA/J	MGP_CBAJ_G0021978	protein coding gene	Chr15:106473088-106506991 (-)
DBA/2J	MGP_DBA2J_G0022105	protein coding gene	Chr15:94866994-94898020 (-)
FVB/NJ	MGP_FVBNJ_G0022084	protein coding gene	Chr15:93855292-93885929 (-)
LP/J	MGP_LPJ_G0022176	protein coding gene	Chr15:99449460-99483384 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022104	protein coding gene	Chr15:110595093-110629088 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022701	protein coding gene	Chr15:98446389-98478560 (-)
PWK/PhJ	MGP_PWKPhJ_G0021274	protein coding gene	Chr15:94964209-94995161 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021108	protein coding gene	Chr15:98216839-98250032 (-)
WSB/EiJ	MGP_WSBEiJ_G0021582	protein coding gene	Chr15:98963909-98997334 (-)

Human Ortholog

RPAP3, RNA polymerase II associated protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPAP3, RNA polymerase II associated protein 3
Synonyms

hSpagh, Tah1
Links

HGNC:26151

NCBI Gene ID: 79657

neXtProt AC: NX_Q9H6T3

UniProt: Q9H6T3
Chr Location

12q13.11; chr12:47661249-47706030 (-) GRCh38

MGI Vertebrate Homology

Rpap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPAP3
Gene Tree

Rpap3

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References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Rpap3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in epithelial cells exhibit impaired proliferation and increased apoptosis in the small intestine.

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All GO Annotations

8
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

57

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpap3

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All Sequences

43
RefSeq

12
UniProt

1
CCDS

CCDS27782.1

Ensembl

ENSMUSG00000022466 (Evidence)
NCBI Gene

71919

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022466	Ensembl Gene Model \| MGI Sequence Detail	30729	C57BL/6J	± kb
transcript	ENSMUST00000023104	Ensembl \| MGI Sequence Detail	2271	Not Applicable
polypeptide	ENSMUSP00000023104	Ensembl \| MGI Sequence Detail	660	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014177 RNA polymerase II-associated protein 3

(term hierarchy)
InterPro Domains

IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR001440 Tetratricopeptide repeat 1

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All nucleic 58

cDNA 57

Primer pair 1

Microarray probesets 3

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MGI:1919169

Summaries

All 56

Diseases 1

Gene Ontology 3

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:314346 Maurizy C, et al., The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021 Aug 10;12(1):4810

TSS for Rpap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136121	Chr15:97603668-97603723 (-)	10 bp
Tssr136120	Chr15:97578353-97578364 (-)	25,347 bp
Tssr136119	Chr15:97578328-97578352 (-)	25,366 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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