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Birc6 Gene Detail
Summary
  • Symbol
    Birc6
  • Name
    baculoviral IAP repeat-containing 6
  • Synonyms
    A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276108
    NCBI Gene: 12211
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74835290-75010351 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 45.64 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4181 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276108
 protein coding gene Chr17:74835247-75010351 (+)
129S1/SvImJ ENSMUSG00200038949
 protein coding gene Chr17:70149252-70325854 (+)
A/J ENSMUSG00195026458
 protein coding gene Chr17:71535484-71711493 (+)
AKR/J ENSMUSG00220018383
 protein coding gene Chr17:70482408-70654481 (+)
BALB/cJ ENSMUSG00180004304
 protein coding gene Chr17:71262391-71438272 (+)
C3H/HeJ ENSMUSG00175014320
 protein coding gene Chr17:70525295-70701159 (+)
C57BL/6NJ ENSMUSG00215022945
 protein coding gene Chr17:70254889-70430774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021879
 protein coding gene Chr17:70439574-70614074 (+)
CAST/EiJ ENSTCUG00005014689
 protein coding gene Chr17:71117689-71291587 (+)
CBA/J ENSMUSG00210027160
 protein coding gene Chr17:70394472-70570356 (+)
DBA/2J ENSMUSG00185012388
 protein coding gene Chr17:73227589-73403488 (+)
FVB/NJ ENSMUSG00205026857
 protein coding gene Chr17:71025953-71201837 (+)
JF1/MsJ ENSUMUG00000012443
 protein coding gene Chr17:72903114-73079857 (+)
LP/J ENSMUSG00230018853
 protein coding gene Chr17:74206185-74382780 (+)
NOD/ShiLtJ ENSMUSG00190026085
 protein coding gene Chr17:70297598-70474193 (+)
NZO/HlLtJ ENSMUSG00225028350
 protein coding gene Chr17:76487196-76659224 (+)
PWK/PhJ ENSLUMG00010027253
 protein coding gene Chr17:70128888-70306560 (+)
SPRET/EiJ ENSMSPG00010016556
 protein coding gene Chr17:70489308-70659672 (+)
WSB/EiJ ENSIUOG00005009565
 protein coding gene Chr17:71240942-71416881 (+)



Homology
more
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
  • Synonyms
    APOLLON, BRUCE
  • Links
    NCBI Gene ID: 57448
    UniProt: Q9NR09

  • Chr Location
    2p22.3; chr2:32357023-32619571 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 6 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    30
  • cDNA Data
    29
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024073 Ensembl Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
    transcript ENSMUST00000182597 Ensembl | MGI Sequence Detail 14649 Not Applicable  
    polypeptide ENSMUSP00000138333 Ensembl | MGI Sequence Detail 4882 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000004754 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
      (term hierarchy)
    • PDB
      8IVQ
    • EC
      2.3.2.24
    • InterPro Domains
      IPR022103 Baculoviral IAP repeat-containing protein 6
      IPR001370 BIR repeat
      IPR016135 Ubiquitin-conjugating enzyme/RWD-like
      IPR000608 Ubiquitin-conjugating (UBC), catalytic core domain
      IPR036322 WD40-repeat-containing domain superfamily
    • GlyGen
      O88738 7 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
    • Latest
      J:378379 Che L, et al., BRUCE liver-KO enhances MASLD/MASH development in the steatotic PTEN-KO background by impairing mitochondrial metabolism and activating STAT3. Cell Death Dis. 2025 Dec 11;17(1):88
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory