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Gnmt Gene Detail
Summary
  • Symbol
    Gnmt
  • Name
    glycine N-methyltransferase
  • Synonyms
    glycine N methyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202304
    NCBI Gene: 14711
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:47036590-47040091 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202304
 protein coding gene Chr17:47036590-47040094 (-)
129S1/SvImJ ENSMUSG00200025308
 protein coding gene Chr17:42235205-42238965 (-)
A/J ENSMUSG00195017722
 protein coding gene Chr17:43739996-43743766 (-)
AKR/J ENSMUSG00220033080
 protein coding gene Chr17:42733854-42737623 (-)
BALB/cJ ENSMUSG00180019030
 protein coding gene Chr17:43490182-43493951 (-)
C3H/HeJ ENSMUSG00175014597
 protein coding gene Chr17:42804075-42807845 (-)
C57BL/6NJ ENSMUSG00215015014
 protein coding gene Chr17:42359418-42363189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021685
 protein coding gene Chr17:43440779-43444048 (-)
CAST/EiJ ENSTCUG00005022589
 protein coding gene Chr17:43521557-43525323 (-)
CBA/J ENSMUSG00210031189
 protein coding gene Chr17:42553772-42557542 (-)
DBA/2J ENSMUSG00185028785
 protein coding gene Chr17:45459167-45462937 (-)
FVB/NJ ENSMUSG00205051552
 protein coding gene Chr17:43029896-43033665 (-)
JF1/MsJ ENSUMUG00000029573
 protein coding gene Chr17:45077819-45081579 (-)
LP/J ENSMUSG00230041348
 protein coding gene Chr17:46351750-46355522 (-)
NOD/ShiLtJ ENSMUSG00190015608
 protein coding gene Chr17:42441426-42445183 (-)
NZO/HlLtJ ENSMUSG00225043044
 protein coding gene Chr17:48606437-48610206 (-)
PWK/PhJ ENSLUMG00010029540
 protein coding gene Chr17:42313784-42317533 (-)
SPRET/EiJ ENSMSPG00010033541
 protein coding gene Chr17:42519151-42522416 (-)
WSB/EiJ ENSIUOG00005025619
 protein coding gene Chr17:43402828-43406588 (-)



Homology
more
  • Human Ortholog
    GNMT, glycine N-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNMT, glycine N-methyltransferase
  • Synonyms
    HEL-S-182mP
  • Links
    NCBI Gene ID: 27232
    UniProt: Q14749

  • Chr Location
    6p21.1; chr6:42960690-42963883 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gnmt mouse models; 1 with human GNMT associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    123
  • cDNA Data
    130
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14711 NCBI Gene Model | MGI Sequence Detail 3502 C57BL/6J ±  kb
    transcript NM_001413152 RefSeq | MGI Sequence Detail 1056 ZRU/MplStud  
    polypeptide Q9QXF8 UniProt | EBI | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 131
      Primer pair 7
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:46123 Aida K, et al., Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997 Dec;29(12):646-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory