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Gnmt Gene Detail
Summary
  • Symbol
    Gnmt
  • Name
    glycine N-methyltransferase
  • Synonyms
    glycine N methyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202304
    NCBI Gene: 14711
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:47036590-47040094 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202304
 protein coding gene Chr17:47036590-47040137 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023830
 protein coding gene Chr17:47813278-47816626 (-)
A/J MGP_AJ_G0023788
 protein coding gene Chr17:46659222-46662687 (-)
AKR/J MGP_AKRJ_G0023759
 protein coding gene Chr17:47006827-47010318 (-)
BALB/cJ MGP_BALBcJ_G0023792
 protein coding gene Chr17:46559430-46562853 (-)
C3H/HeJ MGP_C3HHeJ_G0023555
 protein coding gene Chr17:47751827-47756080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024235
 protein coding gene Chr17:49861526-49864955 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021685
 protein coding gene Chr17:43440779-43444048 (-)
CAST/EiJ MGP_CASTEiJ_G0023037
 protein coding gene Chr17:47841612-47846995 (-)
CBA/J MGP_CBAJ_G0023532
 protein coding gene Chr17:51659964-51664719 (-)
DBA/2J MGP_DBA2J_G0023658
 protein coding gene Chr17:45429048-45432552 (-)
FVB/NJ MGP_FVBNJ_G0023625
 protein coding gene Chr17:45058718-45063000 (-)
LP/J MGP_LPJ_G0023739
 protein coding gene Chr17:48489361-48492831 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023654
 protein coding gene Chr17:51195259-51199584 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024280
 protein coding gene Chr17:47358568-47363281 (-)
PWK/PhJ MGP_PWKPhJ_G0022781
 protein coding gene Chr17:44770413-44773819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022597
 protein coding gene Chr17:44243061-44246317 (-)
WSB/EiJ MGP_WSBEiJ_G0023102
 protein coding gene Chr17:47916602-47921915 (-)



Homology
more
  • Human Ortholog
    GNMT, glycine N-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNMT, glycine N-methyltransferase
  • Synonyms
    HEL-S-182mP
  • Links
    NCBI Gene ID: 27232
    neXtProt AC: NX_Q14749
    UniProt: Q14749

  • Chr Location
    6p21.1; chr6:42960754-42963880 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Gnmt mouse models; 1 with human GNMT associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    114
  • cDNA Data
    130
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002769 Ensembl Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
    transcript ENSMUST00000002846 Ensembl | MGI Sequence Detail 1035 Not Applicable  
    polypeptide ENSMUSP00000002846 Ensembl | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 131
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:46123 Aida K, et al., Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997 Dec;29(12):646-9
    • Latest
      J:312368 Imbard A, et al., Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/21/2023
    MGI 6.22     		The Jackson Laboratory