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Fzd1 Gene Detail
Summary
  • Symbol
    Fzd1
  • Name
    frizzled class receptor 1
  • Synonyms
    Fz1, FZ-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196625
    NCBI Gene: 14362
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:4803839-4808035 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196625
 protein coding gene Chr5:4803839-4808216 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029269
 protein coding gene Chr5:1624434-1628631 (-)
A/J MGP_AJ_G0029232
 protein coding gene Chr5:1547407-1551603 (-)
AKR/J MGP_AKRJ_G0029182
 protein coding gene Chr5:1556623-1560819 (-)
BALB/cJ MGP_BALBcJ_G0029250
 protein coding gene Chr5:1734725-1738922 (-)
C3H/HeJ MGP_C3HHeJ_G0028970
 protein coding gene Chr5:1741853-1746049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029700
 protein coding gene Chr5:1976097-1980293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026943
 protein coding gene Chr5:1665647-1669836 (-)
CAST/EiJ MGP_CASTEiJ_G0028383
 protein coding gene Chr5:1711405-1715607 (-)
CBA/J MGP_CBAJ_G0028931
 protein coding gene Chr5:1922027-1926223 (-)
DBA/2J MGP_DBA2J_G0029083
 protein coding gene Chr5:1684631-1688827 (-)
FVB/NJ MGP_FVBNJ_G0029045
 protein coding gene Chr5:1555956-1560152 (-)
LP/J MGP_LPJ_G0029173
 protein coding gene Chr5:1714731-1718928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029072
 protein coding gene Chr5:1790924-1795121 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029731
 protein coding gene Chr5:1639217-1643413 (-)
PWK/PhJ MGP_PWKPhJ_G0028104
 protein coding gene Chr5:1605899-1610094 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027938
 protein coding gene Chr5:1907352-1911554 (-)
WSB/EiJ MGP_WSBEiJ_G0028463
 protein coding gene Chr5:1648901-1653097 (-)



Homology
more
  • Human Ortholog
    FZD1, frizzled class receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD1, frizzled class receptor 1
  • Links
    NCBI Gene ID: 8321
    neXtProt AC: NX_Q9UP38
    UniProt: Q9UP38

  • Chr Location
    7q21.13; chr7:91264433-91271326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1421
  • Tissues
    378
  • cDNA Data
    78
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044674 Ensembl Gene Model | MGI Sequence Detail 4197 C57BL/6J ±  kb
    transcript ENSMUST00000054294 Ensembl | MGI Sequence Detail 4197 Not Applicable  
    polypeptide ENSMUSP00000058629 Ensembl | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 79
      Primer pair 19
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141181
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 62
      Gene Ontology 14
      Phenotypes 10
    • Earliest
      J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
    • Latest
      J:335089 Zhu X, et al., FZD2 regulates limb development by mediating beta-catenin-dependent and -independent Wnt signaling pathways. Dis Model Mech. 2023 Mar 1;16(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory