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Per2 Gene Detail
Summary
  • Symbol
    Per2
  • Name
    period circadian clock 2
  • Synonyms
    mKIAA0347, mPer2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195265
    NCBI Gene: 18627
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91343699-91387028 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.13 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1216 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195265
 protein coding gene Chr1:91343699-91387046 (-)
129S1/SvImJ ENSMUSG00200036466
 protein coding gene Chr1:88569927-88613449 (-)
A/J ENSMUSG00195030457
 protein coding gene Chr1:88121818-88164902 (-)
AKR/J ENSMUSG00220040394
 protein coding gene Chr1:88279264-88322568 (-)
BALB/cJ ENSMUSG00180015880
 protein coding gene Chr1:88436340-88479251 (-)
C3H/HeJ ENSMUSG00175001318
 protein coding gene Chr1:88307663-88350744 (-)
C57BL/6NJ ENSMUSG00215027297
 protein coding gene Chr1:88244171-88287533 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014424
 protein coding gene Chr1:83869033-83912193 (-)
CAST/EiJ ENSTCUG00005007337
 protein coding gene Chr1:87877731-87919721 (-)
CBA/J ENSMUSG00210011947
 protein coding gene Chr1:88152939-88196018 (-)
DBA/2J ENSMUSG00185013841
 protein coding gene Chr1:92622724-92665815 (-)
FVB/NJ ENSMUSG00205030544
 protein coding gene Chr1:87567314-87610834 (-)
JF1/MsJ ENSUMUG00000015275
 protein coding gene Chr1:91367689-91410975 (-)
LP/J ENSMUSG00230019855
 protein coding gene Chr1:91906082-91949600 (-)
NOD/ShiLtJ ENSMUSG00190025018
 protein coding gene Chr1:88203949-88246997 (-)
NZO/HlLtJ ENSMUSG00225002291
 protein coding gene Chr1:95807481-95850999 (-)
PWK/PhJ ENSLUMG00010041484
 protein coding gene Chr1:87759810-87802810 (-)
SPRET/EiJ ENSMSPG00010039993
 protein coding gene Chr1:89793865-89835088 (-)
WSB/EiJ ENSIUOG00005034447
 protein coding gene Chr1:87866788-87909927 (-)



Homology
more
  • Human Ortholog
    PER2, period circadian regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PER2, period circadian regulator 2
  • Synonyms
    FASPS, FASPS1
  • Links
    NCBI Gene ID: 8864
    UniProt: O15055

  • Chr Location
    2q37.3; chr2:238244044-238300065 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Per2 mouse models; 5 with human PER2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    26 phenotypes from multigenic genotypes
    514 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have a partially functional circadian clock, exhibiting a short circadian period followed by loss of circadian rhythmicity in constant darkness. Mutants are also deficient in DNA damage responses and show increased sensitivity togamma radiation and tumor development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    61
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1188
  • Tissues
    233
  • cDNA Data
    14
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18627 NCBI Gene Model | MGI Sequence Detail 43330 C57BL/6J ±  kb
    transcript NM_011066 RefSeq | MGI Sequence Detail 5815 C57BL/6  
    polypeptide O54943 UniProt | EBI | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 798
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 61
      Phenotypes 514
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:391296 Ferrari M, et al., A High-Throughput Live Imaging Platform to Investigate Circuit-Dependent Regulation of Circadian Rhythms in Brain Tissue. Adv Sci (Weinh). 2026 Jul;13(40):e75427
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory